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Gut bacteria may turn common nutrient into clot-enhancing compound

Date:
April 24, 2017
Source:
American Heart Association
Summary:
Gut bacteria can produce a clot-enhancing compound when people eat a nutrient found in a variety of foods including meat, eggs and milk, according to new research.
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Gut bacteria can produce a clot-enhancing compound when people eat a nutrient found in a variety of foods including meat, eggs and milk, according to new research in the American Heart Association's journal Circulation.

Excessive blood clotting limits or blocks blood flow which can cause heart attack, stroke, damage to the body's organs or death.

The new study provides the first direct evidence in humans that consuming excess choline, an essential nutrient plentiful in a Western diet, raises both levels of the bacteria-produced compound, called trimethylamine N-oxide (TMAO), and the tendency of platelets to clump together and form clots. Numerous studies have shown that higher blood levels of TMAO are associated with a greater risk of heart disease, including heart attacks and strokes in humans, and recent studies showed that feeding animals choline-supplemented diets also raised their risk of clotting.

In this small study, 18 volunteers (8 vegan or vegetarian, 10 omnivores) without heart disease or major risk factors (average age 46 years, 40 percent male), took supplements of 500 milligrams (mg) of choline bitartrate twice daily for two months. The average daily intake is about 302 mg a day.

Researchers found:

  • Blood levels of TMAO rose more than 10 times after both 1 and 2 months of choline supplementation in both vegans/vegetarians and omnivores alike.
  • The tendency of platelets to form clots in a laboratory test rose with choline supplementation.
  • The ability of elevated TMAO levels to promote clot formation was reduced when subjects were also taking a daily baby aspirin (81 mg/day).

"Foods that raise TMAO may increase your risk for clotting and thrombotic events. Unless prescribed by your doctor, avoid supplements with choline. A Mediterranean or vegetarian diet is reported to help reduce TMAO," said Stanley L. Hazen, M.D., Ph.D., senior author of the study, chair of Cellular and Molecular Medicine, and section head of Preventive Cardiology & Rehabilitation at the Cleveland Clinic in Ohio.


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Materials provided by American Heart Association. Note: Content may be edited for style and length.


Journal Reference:

  1. Weifei Zhu, Zeneng Wang, W. H. Wilson Tang, Stanley L. Hazen. Gut Microbe-Generated Trimethylamine N -Oxide From Dietary Choline Is Prothrombotic in Subjects. Circulation, 2017; 135 (17): 1671 DOI: 10.1161/CIRCULATIONAHA.116.025338

Cite This Page:

American Heart Association. "Gut bacteria may turn common nutrient into clot-enhancing compound." ScienceDaily. ScienceDaily, 24 April 2017. <www.sciencedaily.com/releases/2017/04/170424170817.htm>.
American Heart Association. (2017, April 24). Gut bacteria may turn common nutrient into clot-enhancing compound. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2017/04/170424170817.htm
American Heart Association. "Gut bacteria may turn common nutrient into clot-enhancing compound." ScienceDaily. www.sciencedaily.com/releases/2017/04/170424170817.htm (accessed May 28, 2017).

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