Paper test strip could help heart failure patients monitor their condition at home

In the U.S., nearly 6 million people live with heart failure, and about 1 million hospitalizations occur each year are related to the condition, according to the American Heart Association. Closely tracking the condition after diagnosis is important for adjusting treatment and preventing emergency room visits. Antigens called ST2 and BNP are good indicators of heart failure and how it's progressing. But currently, analyzing the levels of these biomarkers requires both trained personnel and sophisticated lab equipment. Feng Xu, Min Lin and colleagues wanted to devise a simple test to enable doctors and patients to carry out the same analysis at the office or at home.

The researchers developed a paper-based test that requires only a small blood sample of 10 microliters. A blue dot glows on the strip if ST2 is present in the sample, and a green dot glows if it contains BNP. The colors' intensities increase with concentration, which indicates a person's heart failure is likely becoming worse. A smartphone app can analyze the readout and send the results to the patient's doctor, who can adjust the patient's treatment accordingly. Testing 38 serum samples from people with heart failure showed that the paper test closely matched conventional techniques.