New! Sign up for our free email newsletter.
Science News
from research organizations

Z-endoxifen shows promise as new treatment for common breast cancer type

Date:
August 30, 2017
Source:
Mayo Clinic
Summary:
Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease, report investigators.
Share:
FULL STORY

Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease. This finding was reported from a clinical trial conducted by researchers at Mayo Clinic and the National Cancer Institute, and published in the Journal of Clinical Oncology.

The final results of a first-in-human phase I study of Z-endoxifen in women with estrogen receptor positive metastatic breast cancer showed that the treatment was safe and resulted in tumor shrinkage in women whose tumors had progressed on standard anti-estrogen therapies, including tamoxifen.

"Tamoxifen, is converted into endoxifen in the liver by an enzyme called CYP2D6. Our previous research found that tamoxifen may be less effective in women with poor CYP2D6 metabolism," says Matthew Goetz, M.D., the study's lead author and an oncologist at Mayo Clinic.

Based on laboratory studies showing that endoxifen better inhibits tumor growth compared to tamoxifen, Dr. Goetz and his colleagues partnered with researchers at the National Cancer Institute to develop Z-endoxifen, an experimental drug unaffected by CYP2D6 metabolism.

"The primary goal of the study was to safely deliver therapeutic levels of endoxifen without the requirement for CYP2D6 liver metabolism," says Dr. Goetz. "However, one of the most surprising observations was the prolonged anticancer benefit, [which] in some cases lasted more than two years in women who had progressed on standard anti-estrogen therapies."

Researchers studied 41 patients with estrogen positive metastatic breast cancer who had progressed on standard anti-estrogen treatments. They concluded that, in patients with metastatic breast cancer who had progressed on standard anti-estrogen treatments, Z-endoxifen provides substantial drug exposure unaffected by CYP2D6 metabolism, acceptable toxicity, and promising anti-tumor activity.

Dr. Goetz and investigators with the Alliance for Clinical Trials in Oncology and the National Cancer Institute recently completed a randomized trial comparing tamoxifen with Z-endoxifen. Results from this trial, A011203, are expected in 2018.

"We are encouraged by these results and [are] hopeful that, based on these data and ongoing studies, Z-endoxifen could become a new U.S. Food and Drug Administration-approved treatment for women with estrogen positive metastatic breast cancer," Dr. Goetz says.


Story Source:

Materials provided by Mayo Clinic. Note: Content may be edited for style and length.


Journal Reference:

  1. Matthew P. Goetz, Vera J. Suman, Joel M. Reid, Don W. Northfelt, Michael A. Mahr, Andrew T. Ralya, Mary Kuffel, Sarah A. Buhrow, Stephanie L. Safgren, Renee M. McGovern, John Black, Travis Dockter, Tufia Haddad, Charles Erlichman, Alex A. Adjei, Dan Visscher, Zachary R. Chalmers, Garrett Frampton, Benjamin R. Kipp, Minetta C. Liu, John R. Hawse, James H. Doroshow, Jerry M. Collins, Howard Streicher, Matthew M. Ames, James N. Ingle. First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer. Journal of Clinical Oncology, 2017; JCO.2017.73.324 DOI: 10.1200/JCO.2017.73.3246

Cite This Page:

Mayo Clinic. "Z-endoxifen shows promise as new treatment for common breast cancer type." ScienceDaily. ScienceDaily, 30 August 2017. <www.sciencedaily.com/releases/2017/08/170830202125.htm>.
Mayo Clinic. (2017, August 30). Z-endoxifen shows promise as new treatment for common breast cancer type. ScienceDaily. Retrieved October 5, 2024 from www.sciencedaily.com/releases/2017/08/170830202125.htm
Mayo Clinic. "Z-endoxifen shows promise as new treatment for common breast cancer type." ScienceDaily. www.sciencedaily.com/releases/2017/08/170830202125.htm (accessed October 5, 2024).

Explore More

from ScienceDaily

RELATED STORIES