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Genetic drivers of most common form of lymphoma identified

More than 150 genetic mutations play a role in diffuse large B cell lymphoma

Date:
October 5, 2017
Source:
Duke University Medical Center
Summary:
An international research effort has been working to better understand the genetic underpinnings of the most prevalent form of lymphoma -- diffuse large B cell lymphoma -- and how those genes might play a role in patients' responses to therapies.
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Lymphoma is the most common blood cancer, but the diagnosis belies a wildly diverse and little understood genetic foundation for the disease that hampers successful treatment.

An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer -- diffuse large B cell lymphoma -- and how those genes might play a role in patients' responses to therapies.

The researchers analyzed tumor samples from 1,001 patients who had been diagnosed with diffuse large B cell lymphoma over the past decade. These patients had been treated at 12 institutions around the world.

Using whole exome sequencing, the researchers pinpointed 150 genetic drivers of the disease, many newly identified. The team then tested to see if there were any correlations between the genes and how well patients had responded to standard therapies. The team applied a genome editing technique known as CRISPR to knock out each of thel 20,000 genes in lymphoma cells to identify those that are critical for lymphoma cells to grow. By assessing the genetic, CRISPR and clinical results, the researchers found several critical genetic links that could help guide treatments.

These findings published online Oct. 5 in the journal Cell.

"This work provides a comprehensive road map in terms of research and clinical priorities," said Sandeep Davé, M.D., professor of medicine at Duke. "We have very good data now to pursue new and existing therapies that might target the genetic mutations we identified. Additionally, this data could also be used to develop genetic markers that steer patients to therapies that would be most effective."


Story Source:

Materials provided by Duke University Medical Center. Note: Content may be edited for style and length.


Journal Reference:

  1. Sandeep S. Dave et al. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell, October 2017 DOI: 10.1016/j.cell.2017.09.027

Cite This Page:

Duke University Medical Center. "Genetic drivers of most common form of lymphoma identified." ScienceDaily. ScienceDaily, 5 October 2017. <www.sciencedaily.com/releases/2017/10/171005125016.htm>.
Duke University Medical Center. (2017, October 5). Genetic drivers of most common form of lymphoma identified. ScienceDaily. Retrieved May 26, 2024 from www.sciencedaily.com/releases/2017/10/171005125016.htm
Duke University Medical Center. "Genetic drivers of most common form of lymphoma identified." ScienceDaily. www.sciencedaily.com/releases/2017/10/171005125016.htm (accessed May 26, 2024).

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