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Interstellar molecules inspire new transformations

Researchers generate 'carbynes' -- a new piece of chemistry's lego

January 31, 2018
Institute of Chemical Research of Catalonia (ICIQ)
When illuminating with LED light, chemists have generated carbynes, a highly reactive chemical species that allowed them to modify drugs like anticancer paclitaxel, antidepressant duloxetine and NSAID ibuprofen.

Back in the 1930s, astronomers detected one of the first molecules in interstellar space -- carbynes. The simplest carbyne, formed by carbon and hydrogen only, is nowadays considered one of the most basic ingredients for life. Despite the impact these molecules could have in synthesis, they had eluded chemists for years. But now, researchers at the Institute of Chemical Research of Catalonia (ICIQ) discovered how to generate carbynes in the lab using visible light and photocatalysts. Led by Dr. Marcos García Suero, they created a new methodology that allows them to create chiral centres adding, like lego pieces, three different fragments to a carbyne.

Carbon has the unique ability to bind four different atoms or molecules forming stable chiral structures. Carbynes are carbon species with a unique characteristic -- three of these four 'slots' are free, ready to form new chemical bonds. This makes them a very reactive and unstable chemical species, hence they have remained largely unexplored in synthetic chemistry. Nevertheless, this interstellar species inspired Suero and his team to design a novel methodology they dubbed "assembly-point functionalization." By carefully choosing different catalytic switches, activated with white or blue LED light, researchers at ICIQ managed to control carbyne precursors, and used them to achieve unprecedented transformations.

Suero and his team used carbynes to add new chiral fragments to already 'finished' molecules, without having to alter the whole synthetic process from scratch -- which is usually very problematic, expensive and time consuming. Suero's group demonstrated the potential of their original idea by functionalizing drugs like duloxetine (antidepressant), paclitaxel (anticancer), fingolimod (multiple sclerosis) or ibuprofen. Moreover, carbynes could be used to connect medicines or drug candidates to specific 'key' fragments, to target them to their corresponding 'keyhole' receptors.

Although in an early stage, this discovery has the potential to significantly accelerate the drug discovery process, hopefully making better medicine available much faster.

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Materials provided by Institute of Chemical Research of Catalonia (ICIQ). Note: Content may be edited for style and length.

Journal Reference:

  1. Zhaofeng Wang, Ana G. Herraiz, Ana M. del Hoyo, Marcos G. Suero. Generating carbyne equivalents with photoredox catalysis. Nature, 2018; 554 (7690): 86 DOI: 10.1038/nature25185

Cite This Page:

Institute of Chemical Research of Catalonia (ICIQ). "Interstellar molecules inspire new transformations." ScienceDaily. ScienceDaily, 31 January 2018. <>.
Institute of Chemical Research of Catalonia (ICIQ). (2018, January 31). Interstellar molecules inspire new transformations. ScienceDaily. Retrieved December 5, 2023 from
Institute of Chemical Research of Catalonia (ICIQ). "Interstellar molecules inspire new transformations." ScienceDaily. (accessed December 5, 2023).

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