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Losing just six hours of sleep could increase diabetes risk, study finds

Sleep deprivation alters liver metabolism and fat content

Date:
September 5, 2018
Source:
American Physiological Society
Summary:
Losing a single night's sleep may affect the liver's ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis (fatty liver) and type 2 diabetes.
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Losing a single night's sleep may affect the liver's ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis (fatty liver) and type 2 diabetes. The findings of the mouse study are published ahead of print in the American Journal of Physiology -- Endocrinology and Metabolism. The research was chosen as an APSselect article for September.

Sleep deprivation has been associated with eating more, moving less and having a higher risk of developing type 2 diabetes. However, a team of researchers from Toho University Graduate School of Medicine in Japan, explained, "It was not clear whether glucose intolerance was due to the changes in food intake or energy expenditure or to the sleep deprivation itself."

The researchers studied two groups of mice: One group was kept awake for six hours each night ("sleep deprivation"), while the control group was allowed to sleep as desired. The research team offered unlimited high-fat food and sugar water -- mimicking lifestyle-related food choices that people make -- to both groups prior to the study. During the sleep/wake period, the animals had limited opportunity for physical activity.

The researchers measured glucose levels and fat content of the liver immediately after the trial period. Blood glucose levels were significantly higher in the sleep deprivation group than controls after one six-hour session of wakefulness. Triglyceride (fat) levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period. Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly. In addition, lack of sleep changed the expression of enzymes that regulate metabolism in the liver in the sleep deprivation group. These findings suggest that "intervention studies designed to prevent sleep deprivation-induced hepatic steatosis and insulin resistance should be performed in the future," the researchers wrote.


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Materials provided by American Physiological Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Fumika Shigiyama, Naoki Kumashiro, Yousuke Tsuneoka, Hiroyuki Igarashi, Fukumi Yoshikawa, Saori Kakehi, Hiromasa Funato, Takahisa Hirose. Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice. American Journal of Physiology-Endocrinology and Metabolism, 2018; DOI: 10.1152/ajpendo.00072.2018

Cite This Page:

American Physiological Society. "Losing just six hours of sleep could increase diabetes risk, study finds." ScienceDaily. ScienceDaily, 5 September 2018. <www.sciencedaily.com/releases/2018/09/180905083901.htm>.
American Physiological Society. (2018, September 5). Losing just six hours of sleep could increase diabetes risk, study finds. ScienceDaily. Retrieved November 12, 2024 from www.sciencedaily.com/releases/2018/09/180905083901.htm
American Physiological Society. "Losing just six hours of sleep could increase diabetes risk, study finds." ScienceDaily. www.sciencedaily.com/releases/2018/09/180905083901.htm (accessed November 12, 2024).

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