New! Sign up for our free email newsletter.
Science News
from research organizations

Regulating blood supply to limbs improves stroke recovery

Noninvasive technique could treat wide variety of stroke patients

Date:
August 19, 2019
Source:
Society for Neuroscience
Summary:
Cutting off and then restoring blood supply to a limb following a stroke reduces tissue damage and swelling and improves functional recovery, according to a new study.
Share:
FULL STORY

Cutting off and then restoring blood supply to a limb following a stroke reduces tissue damage and swelling and improves functional recovery, according to a new study in mice published in JNeurosci. The simple, noninvasive technique could be developed into a treatment for stroke patients of varying severity.

Remote ischemic limb conditioning utilizes a blood pressure cuff and has been shown to aide in stroke recovery, potentially by affecting monocytes. Monocytes are a type of white blood cell involved in immune responses that can either reduce or promote inflammation, which is necessary in the tissue recovery process.

Sunghee Cho and colleagues at Burke Neurological Institute treated mice that experienced a stroke with remote ischemic limb conditioning and tested the monocyte levels in their blood. The research team found that the ratio of inflammatory to non-inflammatory monocytes circulating in the blood increased, resulting in more available inflammatory cells.

Surprisingly, the increase in circulating inflammatory cells was associated with reduced brain tissue damage and swelling and improved motor function. The symptoms improved for both moderate and severe strokes, indicating the potential for wide application as a stroke treatment.


Story Source:

Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.


Journal Reference:

  1. Jiwon Yang, Mustafa Balkaya, Cesar Beltran, Ji Hoe Heo and Sunghee Cho. Remote post-ischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2+ pro-inflammatory subset. Journal of Neuroscience, August 19, 2019: 2699-18 DOI: 10.1523/JNEUROSCI.2699-18.2019

Cite This Page:

Society for Neuroscience. "Regulating blood supply to limbs improves stroke recovery." ScienceDaily. ScienceDaily, 19 August 2019. <www.sciencedaily.com/releases/2019/08/190819132112.htm>.
Society for Neuroscience. (2019, August 19). Regulating blood supply to limbs improves stroke recovery. ScienceDaily. Retrieved October 6, 2024 from www.sciencedaily.com/releases/2019/08/190819132112.htm
Society for Neuroscience. "Regulating blood supply to limbs improves stroke recovery." ScienceDaily. www.sciencedaily.com/releases/2019/08/190819132112.htm (accessed October 6, 2024).

Explore More

from ScienceDaily

RELATED STORIES