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Breakthrough with cancer vaccine

July 9, 2020
Translational Research Institute
Scientists have developed a new cancer vaccine with the potential to activate the body's immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers.

Scientists are ready to trial a new cancer vaccine in humans following the successful outcome of their preclinical studies.

The new vaccine was developed by a Mater Research team based at The Translational Research Institute in collaboration with The University of Queensland.

Lead Researcher Associate Professor Kristen Radford says the vaccine has the potential to treat a variety of blood cancers and malignancies and is a major breakthrough for cancer vaccinations.

"We are hoping this vaccine could be used to treat blood cancers, such as myeloid leukaemia, non-Hodgkin's lymphoma, multiple myeloma, and paediatric leukaemias, plus solid malignancies including breast, lung, renal, ovarian, and pancreatic cancers, and glioblastoma," she said.

"Our new vaccine is comprised of human antibodies fused with tumour-specific protein, and we are investigating its capacity to target human cells while activating the memory of the tumour cells."

Associate Professor Radford says the vaccine offers several key advantages over existing cancer vaccines, which have already shown promise in early clinical trials.

"First, it can be produced as an 'off the shelf' clinical grade formulation, which circumvents the financial and logistical issues associated with patient-specific vaccines," she said.

"Secondly, this prototype vaccine targets the key tumour cells required for the initiation of tumour-specific immune responses, thereby maximising potential effectiveness of treatment, while minimising potential side effects.

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Materials provided by Translational Research Institute. Note: Content may be edited for style and length.

Journal Reference:

  1. Frances E Pearson, Kirsteen M Tullett, Ingrid M Leal‐Rojas, Oscar L Haigh, Kelly‐Anne Masterman, Carina Walpole, John S Bridgeman, James E McLaren, Kristin Ladell, Kelly Miners, Sian Llewellyn‐Lacey, David A Price, Antje Tunger, Marc Schmitz, John J Miles, Mireille H Lahoud, Kristen J Radford. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141 dendritic cells to activate naïve and memory WT1‐specific CD8 T cells. Clinical & Translational Immunology, 2020; 9 (6) DOI: 10.1002/cti2.1141

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Translational Research Institute. "Breakthrough with cancer vaccine." ScienceDaily. ScienceDaily, 9 July 2020. <>.
Translational Research Institute. (2020, July 9). Breakthrough with cancer vaccine. ScienceDaily. Retrieved May 19, 2024 from
Translational Research Institute. "Breakthrough with cancer vaccine." ScienceDaily. (accessed May 19, 2024).

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