Messenger RNA vaccines: Reducing infection from asymptomatic COVID-19 carriers?

With two doses of a messenger RNA COVID-19 vaccine, people with no symptoms showed an 80% lower adjusted risk of testing positive for COVID-19 after their last dose. Those are the findings of a Mayo Clinic study of vaccinated patients. These finding appear in the journal Clinical Infectious Diseases.

The authors say these findings underscore the efficacy of messenger RNA vaccines for COVID-19 to significantly limit the spread of COVID-19 by people with no symptoms who may unknowingly spread the infection to others.

The researchers retrospectively looked at a cohort of 39,000 patients who underwent pre-procedural molecular screening tests for COVID-19. More than 48,000 screening tests were performed, including 3,000 screening tests on patients who had received at least one dose of a messenger RNA COVID-19 vaccine. These screening tests were part of routine COVID-19 testing prior to treatments not related to COVID-19, such as surgeries and other procedures. Patients in the vaccinated group had received at least one dose of a messenger RNA COVID-19 vaccine.

"We found that those patients without symptoms receiving at least one dose of the first authorized mRNA COVID-19 vaccine, Pfizer-BioNTech, 10 days or more prior to screening were 72% less likely to test positive," says Aaron Tande, M.D., a Mayo Clinic infectious diseases specialist and co-first author of the paper. "Those receiving two doses were 73% less likely, compared to the unvaccinated group."

After adjusting for a range of factors, researchers found an 80% risk reduction of testing positive for COVID-19 among those with two doses of a messenger RNA COVID-19 vaccine.

The study was based on patients receiving screening tests between Dec. 17, 2020, and Feb. 8 at Mayo Clinic in Minnesota and Arizona and at Mayo Clinic Health System in Minnesota and Wisconsin.

Additional authors are Benjamin Pollock, Ph.D., co-first author; Nilay Shah, Ph.D.; Gianrico Farrugia, M.D.; Abinash Virk, M.D.; Melanie Swift, M.D.; Laura Breeher, M.D.; Matthew Binnicker, Ph.D.; and Elie Berbari, M.D. ? all of Mayo Clinic. Funding for the study was provided by Mayo Clinic.