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Potential new CAR-T cell therapy for multiple myeloma

Date:
June 25, 2021
Source:
Mayo Clinic
Summary:
Researchers are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma.
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Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma. Their findings were published on Friday, June 24, in The Lancet.

"CAR-T cell therapy is a type of immunotherapy that involves harnessing the power of a person's own immune system by engineering their T cells to recognize and destroy cancer cells," says Yi Lin, M.D., a Mayo Clinic hematologist and lead author of the study.

Dr. Lin says the Food and Drug Administration approved idecabtagene vicleucel, the first CAR-T cell treatment for multiple myeloma, in March. "Today, we are working toward another potential CAR-T cell treatment for multiple myeloma," says Dr. Lin.

Dr. Lin says the CARTITUDE-1 study is a registration-phase 1B/II clinical trial. The trial tested B cell maturation antigen targeting CAR-T cell therapy, ciltacabtagene autoleucel (cilta-cel), in patients with multiple myeloma who received at least three previous lines of therapy with standard drugs, including proteasome inhibitors, immunomodulatory drugs and CD38 antibodies.

"Cilta-cel is made from patient's own T cells that have been genetically engineered and administered as a single dose infusion," says Dr. Lin.

Dr. Lin says the overall response rate to the treatment was 97%, while the complete response rate and progression-free survival rates were 67% and 77%, respectively. The overall survival rate was 89%.

"Updates on this study were also recently presented at the American Society of Clinical Oncology annual meeting, which occurred after our paper was accepted for publication in The Lancet," says Dr. Lin. "Our ASCO presentation showed a continued deepening response for patients receiving this therapy, with a complete response rate of 80%," says Dr. Lin. "These are very impressive results for myeloma patients who have already gone through many lines of therapy for their disease."

Going forward, Dr. Lin says it will be important to better understand the clinical features of patients who have experienced durable remissions on this therapy and the mechanisms behind patients who relapse.

"While comparisons cannot be formally made across two separate single-arm studies of ide-cel and cilta-cel, the impressive high response rate and progression-free survival of patients treated with cilta-cel are very exciting," says Dr. Lin.

She cautions, however, that the potential translation of this research into a clinical individualized therapy will require solving many logistical details, including ensuring that the transition from manufacturing for research to a commercial product remains reliable.


Story Source:

Materials provided by Mayo Clinic. Original written by Joe Dangor. Note: Content may be edited for style and length.


Journal Reference:

  1. Jesus G Berdeja, Deepu Madduri, Saad Z Usmani, Andrzej Jakubowiak, Mounzer Agha, Adam D Cohen, A Keith Stewart, Parameswaran Hari, Myo Htut, Alexander Lesokhin, Abhinav Deol, Nikhil C Munshi, Elizabeth O'Donnell, David Avigan, Indrajeet Singh, Enrique Zudaire, Tzu-Min Yeh, Alicia J Allred, Yunsi Olyslager, Arnob Banerjee, Carolyn C Jackson, Jenna D Goldberg, Jordan M Schecter, William Deraedt, Sen Hong Zhuang, Jeffrey Infante, Dong Geng, Xiaoling Wu, Marlene J Carrasco-Alfonso, Muhammad Akram, Farah Hossain, Syed Rizvi, Frank Fan, Yi Lin, Thomas Martin, Sundar Jagannath. Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study. The Lancet, 2021; DOI: 10.1016/S0140-6736(21)00933-8

Cite This Page:

Mayo Clinic. "Potential new CAR-T cell therapy for multiple myeloma." ScienceDaily. ScienceDaily, 25 June 2021. <www.sciencedaily.com/releases/2021/06/210625173204.htm>.
Mayo Clinic. (2021, June 25). Potential new CAR-T cell therapy for multiple myeloma. ScienceDaily. Retrieved October 5, 2024 from www.sciencedaily.com/releases/2021/06/210625173204.htm
Mayo Clinic. "Potential new CAR-T cell therapy for multiple myeloma." ScienceDaily. www.sciencedaily.com/releases/2021/06/210625173204.htm (accessed October 5, 2024).

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