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MRI, clear cell likelihood score correlate with renal mass growth rate

Date:
July 22, 2021
Source:
American Roentgen Ray Society
Summary:
The standardized non-invasive clear cell likelihood score (ccLS) -- derived from MRI -- correlates with the growth rate of small renal masses and may help guide personalized management.
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According to ARRS' American Journal of Roentgenology (AJR), the standardized non-invasive clear cell likelihood score (ccLS) -- derived from MRI -- correlates with the growth rate of small renal masses (cT1a, <4 cm) and may help guide personalized management.

Extracted from clinical reports, "the ccLS scores the likelihood that the small renal mass represents clear cell renal cell carcinoma, from 1 (very unlikely) to 5 (very likely)," explained corresponding author Ivan Pedrosa from the University of Texas Southwestern Medical Center at Dallas. "Small renal masses with lower ccLS may be considered for active surveillance, whereas small renal masses with higher ccLS may warrant earlier intervention."

Pedrosa and colleagues' retrospective study included consecutive small renal masses assigned a ccLS on clinical MRI examinations performed between June 2016 and November 2019 at an academic tertiary-care medical center or its affiliated safety net hospital system. Tumor size measurements were extracted from available prior and follow-up cross-sectional imaging examinations, through June 2020.

Among 389 small renal masses in 339 patients (198 men, 141 women; median age, 65 years) on active surveillance that were assigned a ccLS on clinical MRI examinations, those with ccLS4-5 grew significantly faster (9% diameter, 29% volume yearly) than those with ccLS1-2 (5% diameter, p<.001; 16% volume, p<.001) or ccLS3 (4% diameter, p<.001; 15% volume, p<.001).

Noting that the lack of validated imaging markers to characterize biologic aggressiveness of small renal masses hinders medical decision making among available initial management strategies, "growth is associated with ccLS in small renal masses," the authors of this AJR article reiterated, "with higher ccLS correlating with faster growth."


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Materials provided by American Roentgen Ray Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Robert G. Rasmussen, Yin Xi, R. Carson Sibley, Christopher Lee, Jeffrey A. Cadeddu, Ivan Pedrosa. Association of Clear Cell Likelihood Score on MRI and Growth Kinetics of Small Solid Renal Masses on Active Surveillance. American Journal of Roentgenology, 2021; DOI: 10.2214/AJR.21.25979

Cite This Page:

American Roentgen Ray Society. "MRI, clear cell likelihood score correlate with renal mass growth rate." ScienceDaily. ScienceDaily, 22 July 2021. <www.sciencedaily.com/releases/2021/07/210722112459.htm>.
American Roentgen Ray Society. (2021, July 22). MRI, clear cell likelihood score correlate with renal mass growth rate. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2021/07/210722112459.htm
American Roentgen Ray Society. "MRI, clear cell likelihood score correlate with renal mass growth rate." ScienceDaily. www.sciencedaily.com/releases/2021/07/210722112459.htm (accessed March 28, 2024).

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