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A novel therapy using unique thermogel prevents retinal scarring

Date:
July 4, 2022
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Scientists have developed a bio-functional thermogel, a type of synthetic polymer, to prevent retinal scarring caused by failed retinal detachment repair surgery. Proliferative vitreoretinopathy (PVR) occurs when the retinal scarring prevents the retina from healing and falling back into place, and accounts for more than 75 per cent of failed retinal detachment surgeries, and may result in vision loss or blindness if left unrepaired.
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Singapore scientists have developed a bio-functional thermogel, a type of synthetic polymer, to prevent retinal scarring caused by failed retinal detachment repair surgery. Proliferative vitreoretinopathy (PVR) occurs when the retinal scarring prevents the retina from healing and falling back into place, and accounts for more than 75 per cent of failed retinal detachment surgeries, and may result in vision loss or blindness if left unrepaired.

Current treatment options for PVR are limited to surgical removal of these scar membranes with guarded visual recovery. This work highlights the potential of using synthetic polymers alone to modulate cellular behaviour and for the first time, offers a novel thermogel-based therapy to prevent retinal scarring. The team behind the development hails from A*STAR's Institute of Molecular and Cell Biology (IMCB) and Institute of Materials Research and Engineering (IMRE), the National University of Singapore (NUS) and the Singapore Eye Research Institute (SERI).

The research team demonstrated that a bio-functional thermogel alone is able to prevent retinal scarring in a pre-clinical model that mimics human disease. Using retinal cells, the team observed that the thermogel prevented the development of the scar membranes by modulating cellular behaviours such as proliferation and migration. Using genome-wide transcriptomic analysis to profile cellular gene expression, they revealed that the thermogel activated a protein called nuclear factor erythroid 2-related factor 2 (NRF2), to kickstart a series of chemical reactions to prevent scarring.

"Our study offers insight into how synthetic polymers no longer function merely as inert drug carriers. It challenges the conventional belief that the use of a small molecule drug is always required to achieve a therapeutic effect. Beyond ophthalmology, this unique bio-functionality of the thermogel can also be applied to other diseases such as orthopaedics where intra-articular joint scarring might be a problem," said Dr Su Xinyi, Senior Principal Investigator and Division Director at A*STAR's IMCB, and Assistant Professor in the Department of Ophthalmology at NUS Yong Loo Lin School of Medicine.

"When we first developed this bio-functional thermogel at IMRE, we realised it was a significant step forward in developing next-generation biodegradable polymers. Its ability to mimic and substitute vitreous given the biocompatibility of the material, makes it useful for many other biomedical applications," said Prof Loh Xian Jun, Executive Director at A*STAR's IMRE.

The thermogel is currently being commercialised by Vitreogel Innovations Inc, an A*STAR spin-off that focuses on developing polymer-based therapeutics for ophthalmology indications. Vitreogel Innovations Inc is an ISO 13485 (Medical Device Quality Systems) accredited company that is generating a clinical grade version of the polymer for first-in-man clinical trials.

Building on this work, the team will continue to test the safety and efficacy of this polymer for retinal detachment repair and PVR prevention using additional pre-clinical disease models. Through their work, the team aims to engineer the next generation of polymers with targeted chemical modifications to elicit specific cellular behaviours, and identify alternative applications of the thermogel beyond ophthalmology.


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Materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Content may be edited for style and length.


Journal Reference:

  1. Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, Sowmiya R, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su. A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-30474-6

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "A novel therapy using unique thermogel prevents retinal scarring." ScienceDaily. ScienceDaily, 4 July 2022. <www.sciencedaily.com/releases/2022/07/220704094224.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2022, July 4). A novel therapy using unique thermogel prevents retinal scarring. ScienceDaily. Retrieved March 4, 2024 from www.sciencedaily.com/releases/2022/07/220704094224.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "A novel therapy using unique thermogel prevents retinal scarring." ScienceDaily. www.sciencedaily.com/releases/2022/07/220704094224.htm (accessed March 4, 2024).

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