Gene Therapy News
April 28, 2017

Latest Headlines
updated 9:28pm EDT

More Gene Therapy News
April 28, 2017

Genetic Profile of Treatment-Resistant Lung Cancer More Variable Than Previously Thought

Mar. 16, 2017 — The genetic mutations underlying treatment resistance in non-small cell lung cancer (NSCLC) are more complex and dynamic than previously ... read more

CAR T Cells More Powerful When Built With CRISPR, Researchers Find

Feb. 22, 2017 — Researchers have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in ... read more

Feb. 13, 2017 — Scientists have discovered a new "mastermind fusion gene" may be associated with a rare cancer-causing tumor -- pheochromocytomas ("pheo") and paragangliomas -- according to a ... read more

Researchers Identify 'Synthetic Essentiality' as Novel Approach for Locating Cancer Therapy Targets

Feb. 6, 2017 — A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes. The process, which located a genetic site for the most common form of prostate ... read more

Feb. 6, 2017 — In the summer of 2015, a team of scientists eported restoring rudimentary hearing in genetically deaf mice using gene therapy. Now the research team reports restoring a much higher level of hearing ... read more

Jan. 31, 2017 — A new study reveals a new molecular mechanism essential for associative memory encoding in the hippocampus. This brain region is highly affected pathologically at early stages of several ... read more

Jan. 27, 2017 — A newly found 'survival gene' stops strains of TB mutating into deadly 'superbugs,' outlines a new report. The discovery of a gene called NucS that dramatically reduces mutation ... read more

Jan. 26, 2017 — Using a novel form of gene therapy, scientists have managed to restore partial hearing and balance in mice born with a genetic condition that affects ... read more

Gene Therapy for Pompe Disease Effective in Mice, Poised for Human Trials

Jan. 26, 2017 — After decades investigating a rare, life-threatening condition that cripples the muscles, researchers have developed a gene therapy they hope could enhance or even replace the only FDA-approved ... read more

'Collateral' Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

Jan. 18, 2017 — Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as 'collateral lethality,' which may create new ... read more

Jan. 12, 2017 — Researchers have harnessed the CRISPR-Cas9 technology to correct mutations in the blood stem cells of patients with a rare immunodeficiency disorder; the engineered cells successfully engrafted in ... read more

Unique Gene Signature Predicts Potentially Lethal Prostate Cancers

Jan. 10, 2017 — Standard therapy for prostate cancer, the third-leading cause of cancer-related deaths in American men, is based on blocking androgens, the male sex hormones. However, for some men, prostate cancer ... read more

Research Helps Explain Why Androgen-Deprivation Therapy Doesn't Work for Many Prostate Cancers

Jan. 5, 2017 — Metastatic prostate cancer, or prostate cancer that has spread to other organs, is incurable. In new research, scientists have identified two gatekeeper genes that allow prostate cancer to progress ... read more

Immunotherapy, Gene Therapy Combination Shows Promise Against Glioblastoma

Jan. 4, 2017 — In a new study, gene therapy deployed with immune checkpoint inhibitors demonstrates potential benefit for devastating brain ... read more

Mechanism of Successful Horizontal Gene Transfer Between Divergent Organisms Explained

Dec. 20, 2016 — Researchers have shown how a host's gene regulatory environment can facilitate the establishment of a gene newly arrived via horizontal transfer. Studying the cellulose synthase gene in ... read more

Dec. 14, 2016 — Breast cancer cells that carry a certain gene mutation can be induced to die using a combination of an existing targeted therapy along with an investigational molecule tested by ... read more

Enzyme That Regulates DNA Repair May Offer New Precision Treatments for Breast and Ovarian Cancer

Dec. 12, 2016 — Researchers have identified an enzyme called UCHL3 that regulates the BRCA2 pathway, which is important for DNA repair, report ... read more

Loss of ARID1A Protein Drives Onset, Progress of Colon Cancer

Dec. 12, 2016 — A team of scientists has developed a model system in mice that allows them to look closely at how a protein often mutated in human cancer exerts its tumor-silencing effects. The new findings shed ... read more

After One Dose of Gene Therapy, Hemophilia B Patients Maintain Near-Normal Levels of Clotting Factor

Dec. 3, 2016 — Researchers are reporting the highest and most sustained levels to date of an essential blood-clotting factor IX in patients with the inherited bleeding disorder hemophilia B. After receiving a ... read more

Nov. 30, 2016 — CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations. For the first time, researchers have developed a dual gene therapy approach to ... read more

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