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Researchers identify proteins associated with deadly burns

Date:
July 18, 2023
Source:
Osaka University
Summary:
The physiological mechanisms underlying severe burns are not well understood. Researchers used mass spectrometry to identify key blood proteins associated with burn mortality. Ultimately, three proteins (HBA1, TTR, SERPINF2) were very highly correlated with morality rates. Further research into these proteins and their pathways may lead to better drugs to treat people with life-threatening burns.
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Although many people still die from severe burns, the underlying physiology behind burns is not well understood. In an article published in iScience, researchers from Osaka University identified key proteins associated with mortality in people with life-threatening burns.

Proteomics is the large-scale study of an organism's entire set of proteins. Recent developments in mass spectrometry -- an analytic technique used to identify chemical substances -- have improved the feasibility of proteomic analysis, enabling the identification of hundreds to thousands of proteins at a time.

Shinya Onishi, the study's lead author, emphasizes that proteomic analysis of burns is still in its infancy. "Burns are known to cause severe circulatory, immune, metabolic, and coagulation system dysregulation," he says. "For example, right after an injury, there is an immediate increase in capillary permeability, which is one of the main factors leading to circulatory failure. However, the details behind many of these mechanisms are still unclear."

The retrospective observational study included ten healthy volunteers and 83 burn patients, 15 of whom died within 28 days of injury. Proteins in plasma samples were analyzed using mass spectrometry. The authors then performed various statistical analyses to understand how differences in protein levels correlated with burn severity.

Jun Oda, a senior author of the study, highlights the two underlying goals of the study: "The first goal is to identify previously unidentified proteins that might be associated with the pathogenesis of life-threatening burns," he says. "The second goal is to investigate novel molecular pathways in burn victims that might be the targets of future drugs."

Ultimately, ten proteins were identified that were strongly associated with mortality.

Furthermore, three of those proteins (HBA1, TTR, and SERPINF2) showed the highest association with mortality and were used by the researchers to classify patients (also known as clinical phenotyping) into three groups corresponding to mortality rates. The group which had the highest mortality, was characterized by higher levels of HBA1 and lower levels of TTR and SERPINF2.

One of the proteins, HBA1, is associated with hemoglobin, while another, TTR, is an indicator of the breakdown of proteins in the body. Finally, the third protein, SERPINF2, is associated with the development and dissolution of blood clots. Onishi emphasizes that "these three proteins can function as important prognostic biomarkers for burn patients." Therefore, future research on these proteins and their pathways is necessary as they are promising targets for developing new therapeutic strategies and drugs for severe burns.


Story Source:

Materials provided by Osaka University. Note: Content may be edited for style and length.


Journal Reference:

  1. Shinya Onishi, Hisatake Matsumoto, Fuminori Sugihara, Takeshi Ebihara, Hiroshi Matsuura, Akinori Osuka, Daisuke Okuzaki, Hiroshi Ogura, Jun Oda. Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome. iScience, 2023; 26 (8): 107271 DOI: 10.1016/j.isci.2023.107271

Cite This Page:

Osaka University. "Researchers identify proteins associated with deadly burns." ScienceDaily. ScienceDaily, 18 July 2023. <www.sciencedaily.com/releases/2023/07/230718105728.htm>.
Osaka University. (2023, July 18). Researchers identify proteins associated with deadly burns. ScienceDaily. Retrieved April 20, 2024 from www.sciencedaily.com/releases/2023/07/230718105728.htm
Osaka University. "Researchers identify proteins associated with deadly burns." ScienceDaily. www.sciencedaily.com/releases/2023/07/230718105728.htm (accessed April 20, 2024).

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