New! Sign up for our free email newsletter.
Science News
from research organizations

Macaque trials offer hope in pneumonia vaccine development

Development of a novel pneumococcal vaccine with confirmed efficacy in macaque monkeys

Date:
November 28, 2023
Source:
Osaka Metropolitan University
Summary:
A research team has successfully developed a novel pneumococcal vaccine by combining the team's proprietary mucosal vaccine technology with pneumococcal surface proteins that can cover a wide range of serotypes. Experiments were conducted using mice and macaques and it was confirmed that pneumonia caused by pneumococcal infection was clearly suppressed in the target groups of animals inoculated with the vaccine.
Share:
FULL STORY

The global impact of the coronavirus pandemic has ignited a renewed focus on emerging and re-emerging infectious diseases. Researchers at Osaka Metropolitan University are making great strides in combating pneumococcal pneumonia, one of the leading causes of respiratory deaths worldwide.

Despite the existence of vaccines against pneumococcal infections such as otitis media, sinusitis, and meningitis, the prevalence of pneumococcal pneumonia remains high. Currently, around 100 new serotypes of Streptococcus pneumoniae have been identified, and the increase in pneumococcal infections caused by serotypes not covered by the vaccine has become a concern. This situation underscores the need for a more versatile vaccine.

Building on their previous success in mucosal responses in 2019, in which they developed a mucosal vaccine that caninduce antigen-specific mucosal immune responses, mainly immunoglobulin A (IgA), on the target mucosal surface, a research team led by Professor Satoshi Uematsu and Associate Professor Kosuke Fujimoto from the Department of Immunology and Genomics at the Graduate School of Medicine, Osaka Metropolitan University, has this time set out to bridge the gap in pneumococcal pneumonia vaccination efficacy.

To successfully develop a novel pneumococcal vaccine, the research team combined its proprietary mucosal vaccine technology with pneumococcal surface proteins that can cover a wide range of serotypes. Experiments conducted on mice and macaques have demonstrated the vaccine's efficacy in suppressing pneumococcal pneumonia in the target animal groups.

"This research has succeeded in developing a vaccine formulation that can potentially be used in humans, which will advance the development of this vaccine for clinical applications," said Professor Fujimoto. "This next-generation vaccine technology is expected to contribute to the treatment of infectious diseases in the future."


Story Source:

Materials provided by Osaka Metropolitan University. Note: Content may be edited for style and length.


Journal Reference:

  1. Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro Sato, Muneki Hotomi, Yukihiro Akeda, Ken J. Ishii, Yasuhiro Yasutomi, Kishiko Sunami, Satoshi Uematsu. Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci. Inflammation and Regeneration, 2023; 43 (1) DOI: 10.1186/s41232-023-00305-2

Cite This Page:

Osaka Metropolitan University. "Macaque trials offer hope in pneumonia vaccine development." ScienceDaily. ScienceDaily, 28 November 2023. <www.sciencedaily.com/releases/2023/11/231128132429.htm>.
Osaka Metropolitan University. (2023, November 28). Macaque trials offer hope in pneumonia vaccine development. ScienceDaily. Retrieved February 23, 2024 from www.sciencedaily.com/releases/2023/11/231128132429.htm
Osaka Metropolitan University. "Macaque trials offer hope in pneumonia vaccine development." ScienceDaily. www.sciencedaily.com/releases/2023/11/231128132429.htm (accessed February 23, 2024).

Explore More
from ScienceDaily

RELATED STORIES