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Health researchers develop software to predict diseases

January 23, 2024
Rutgers University
IntelliGenes analyzes genomic data to discover biomarkers associated with health traits.

IntelliGenes, a first of its kind software created at Rutgers Health, combines artificial intelligence (AI) and machine-learning approaches to measure the significance of specific genomic biomarkers to help predict diseases in individuals, according to its developers.

A study published in Bioinformatics explains how IntelliGenes can be utilized by a wide range of users to analyze multigenomic and clinical data.

Zeeshan Ahmed, lead author of the study and a faculty member at Rutgers Institute for Health, Health Care Policy and Aging Research (IFH), said there currently are no AI or machine-learning tools available to investigate and interpret the complete human genome, especially for nonexperts. Ahmed and members of his Rutgers lab designed IntelliGenes so anyone can use the platform, including students or those without strong knowledge of bioinformatics techniques or access to high-performing computers.

The software combines conventional statistical methods with cutting-edge machine learning algorithms to produce personalized patient predictions and a visual representation of the biomarkers significant to disease prediction.

In another study, published in Scientific Reports, the researchers applied IntelliGenes to discover novel biomarkers and predict cardiovascular disease with high accuracy.

"There is huge potential in the convergence of datasets and the staggering developments in artificial intelligence and machine learning," said Ahmed, who also is an assistant professor of medicine at Robert Wood Johnson Medical School.

"IntelliGenes can support personalized early detection of common and rare diseases in individuals, as well as open avenues for broader research ultimately leading to new interventions and treatments."

Researchers tested the software using Amarel, the high-performance computing cluster managed by the Rutgers Office of Advanced Research Computing. The office provides a research computing and data environment for Rutgers researchers engaged in complex computational and data-intensive projects.

Coauthors of the study include William DeGroat, Dinesh Mendhe, Atharva Bhusari and Habiba Abdelhalim of IFH and Saman Zeeshan of Rutgers Cancer Institute of New Jersey.

Story Source:

Materials provided by Rutgers University. Original written by Nicole Swenarton. Note: Content may be edited for style and length.

Journal Reference:

  1. William DeGroat, Dinesh Mendhe, Atharva Bhusari, Habiba Abdelhalim, Saman Zeeshan, Zeeshan Ahmed. IntelliGenes: a novel machine learning pipeline for biomarker discovery and predictive analysis using multi-genomic profiles. Bioinformatics, 2023; 39 (12) DOI: 10.1093/bioinformatics/btad755

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Rutgers University. "Health researchers develop software to predict diseases." ScienceDaily. ScienceDaily, 23 January 2024. <>.
Rutgers University. (2024, January 23). Health researchers develop software to predict diseases. ScienceDaily. Retrieved February 28, 2024 from
Rutgers University. "Health researchers develop software to predict diseases." ScienceDaily. (accessed February 28, 2024).

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