New! Sign up for our free email newsletter.
Science News
from research organizations

Healing eyes with contact lenses

Patented bandage contact lens material could release drugs as needed to help eye abrasions heal faster

Date:
March 21, 2024
Source:
University of Waterloo
Summary:
A cross-disciplinary team has developed a new contact lens material that could act as a bandage for corneal wounds while releasing drugs in a controlled manner to help the eye heal faster.
Share:
FULL STORY

A cross-disciplinary University of Waterloo team has developed a new contact lens material that could act as a bandage for corneal wounds while releasing drugs in a controlled manner to help the eye heal faster.

Typically, corneal abrasion patients spend seven to 10 days wearing a clear, oxygen-permeable bandage contact lens, often instilled with eyedrops containing antibiotics. However, the one-time antibiotic application makes it difficult to ensure enough drugs stay on the eye for sustained treatment.

"It's a targeted-release drug delivery system that is responsive to the body," said Dr. Lyndon Jones, a professor at Waterloo's School of Optometry & Vision Science and director of the Centre for Ocular Research & Education (CORE). "The more injured you are, the more drug gets delivered, which is unique and potentially a game changer."

Jones knew there was a market for a drug-delivering bandage contact lens that could simultaneously treat the eye and allow it to heal. The question was how to develop it.

As the University of Waterloo has several researchers and entrepreneurs building technology to disrupt the boundaries of health, Jones was able to team up with Dr. Susmita Bose (PhD'23), Dr. Chau-Minh Phan (PhD'16) and Dr. Evelyn Yim, an associate professor of chemical engineering working on collagen-based materials. Rounding out the team were Dr. Muhammad Rizwan, a former postdoctoral fellow, and John Waylon Tse (MASc'18), a former graduate student, both with Yim's lab.

Collagen is a protein naturally found in the eye that's also often involved in the wound healing process -- however, it's too soft and weak to be a contact lens material. Yim found a way to transform gelatin methacrylate, a collagen derivative, into a biomaterial 10 times stronger.

One unique property of collagen-based materials is that they degrade when exposed to an enzyme called matrix metalloproteinase-9 (MMP-9), which is naturally found in the eye.

"These enzymes are very special because they're involved in wound healing, and when you have a wound, they're released in greater quantity," Phan said. "If you have a material that can be degraded in the presence of this enzyme, and we add a drug to this material, we can engineer it so it releases the drug in a way that is proportional to the amount of enzymes present at the wound. So, the bigger the wound, the higher the amount of drug released."

The team used bovine lactoferrin as a model wound-healing drug and entrapped it in the material. In human cell culture study, the researchers achieved complete wound healing within five days using the drug-releasing novel contact lens material.

Another benefit of the material is that it only becomes activated at eye temperatures, providing an inbuilt storage mechanism.

The next step is fine-tuning the material, including entrapping different drugs in it.

The scientists believe their material has great potential -- not only for the eye but potentially for other body sites, especially large skin ulcers.

A study outlining the researchers' work was recently published in the journal Pharmaceutics.


Story Source:

Materials provided by University of Waterloo. Note: Content may be edited for style and length.


Journal Reference:

  1. Susmita Bose, Chau-Minh Phan, Muhammad Rizwan, John Waylon Tse, Evelyn Yim, Lyndon Jones. Fabrication and Characterization of an Enzyme-Triggered, Therapeutic-Releasing Hydrogel Bandage Contact Lens Material. Pharmaceutics, 2023; 16 (1): 26 DOI: 10.3390/pharmaceutics16010026

Cite This Page:

University of Waterloo. "Healing eyes with contact lenses." ScienceDaily. ScienceDaily, 21 March 2024. <www.sciencedaily.com/releases/2024/03/240321001158.htm>.
University of Waterloo. (2024, March 21). Healing eyes with contact lenses. ScienceDaily. Retrieved April 24, 2024 from www.sciencedaily.com/releases/2024/03/240321001158.htm
University of Waterloo. "Healing eyes with contact lenses." ScienceDaily. www.sciencedaily.com/releases/2024/03/240321001158.htm (accessed April 24, 2024).

Explore More

from ScienceDaily

RELATED STORIES