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The gender gap in life expectancy: Are eggs and sperm partly responsible?

Researchers studying killifish discover that reproductive cells drive sex-dependent differences in lifespan and reveal a role for vitamin D in improving longevity

June 12, 2024
Osaka University
Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.

Women live longer than men. This isn't unique to humans, either; we see this trend in a wide range of other animals. Biologists have theorized that the discrepancy in life expectancy between sexes might be partly related to reproduction, but how?

In a study published in Science Advances, researchers from Osaka University have discovered for the first time that germ cells, the cells that develop into eggs in females and sperm in males, drive sex-dependent lifespan differences in vertebrate animals.

The researchers examined aging in the turquoise killifish, a small, fast-growing freshwater fish with a lifespan of only a few months. As in humans, female killifish live longer than males. However, when the researchers removed the germ cells from these fish, they found that males and females had similar lifespans.

"After removing the germ cells, male killifish lived longer than usual and female lifespans became shorter," explains lead author Kota Abe. "We wanted to understand how germ cells could affect males and females so differently. Our next step was to investigate the factors responsible."

The team found that hormonal signaling was very different in females than in males. Female killifish without germ cells had significantly less estrogen signaling, which can shorten lifespan by increasing cardiovascular disease risk. The females also had significantly more growth factor signaling (insulin-like growth factor 1). This made the females grow larger while also suppressing signals within the body important for maintaining health and slowing aging.

In contrast, male killifish without germ cells had improved muscle, skin, and bone health. Interestingly, these fish had increased amounts of a substance that activates vitamin D, as well as evidence of vitamin D signaling in their muscles and skin.

Vitamin D can also be considered a hormone; while well known for keeping bones strong and healthy, it also seems to have wider positive effects throughout the body. The team's results pointed to the possibility that vitamin D can improve longevity, leading them to test whether a vitamin D supplement could increase the lifespan of the fish.

"When we administered active vitamin D, we found that the lifespans of both males and females were significantly extended, suggesting that vitamin D signaling provides health benefits throughout the body," explains senior author Tohru Ishitani. "Our work suggests that vitamin D signaling could influence the longevity of other vertebrates, including humans."

The discovery that germ cells affect male and female longevity in opposing ways is an important clue in unravelling the mysterious interactions between reproduction, aging, and lifespan. It's unclear exactly how vitamin D fits into this puzzle, but it could be part of future strategies to extend healthy lifespans.

Story Source:

Materials provided by Osaka University. Note: Content may be edited for style and length.

Journal Reference:

  1. Kota Abe, Hikaru Ino, Tomomi Niwa, Daniel Semmy, Ayami Takaochi, Takashi Nishimura, Chihiro Mogi, Maki Uenaka, Masaru Ishii, Kaori Tanaka, Yasuyuki Ohkawa, Tohru Ishitani. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Science Advances, 2024; 10 (24) DOI: 10.1126/sciadv.adi1621

Cite This Page:

Osaka University. "The gender gap in life expectancy: Are eggs and sperm partly responsible?." ScienceDaily. ScienceDaily, 12 June 2024. <>.
Osaka University. (2024, June 12). The gender gap in life expectancy: Are eggs and sperm partly responsible?. ScienceDaily. Retrieved July 17, 2024 from
Osaka University. "The gender gap in life expectancy: Are eggs and sperm partly responsible?." ScienceDaily. (accessed July 17, 2024).

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