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Risk factors for long COVID revealed

June 17, 2024
Columbia University Irving Medical Center
A new study sheds light on factors that may have predisposed some patients to recover more slowly after COVID.

Early in the pandemic, many people who had SARS-Cov-2 infection or COVID-19 began to report that they couldn't shake off their symptoms even after a month or more -- unusually long for a viral infection of the upper respiratory tract -- or developed new, persistent symptoms soon after the infection cleared.

Although it's still not clear what causes post-COVID-19 conditions or "long COVID" (symptoms and conditions that develop, linger, or reoccur weeks or months after SARS-CoV-2 infection), a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons confirms the high burden of long COVID and sheds light on who's at greatest risk.

The study found that people with a milder infection -- including those who were vaccinated against SARS-CoV-2 and those who were infected with an Omicron variant -- were more likely to recover quickly.

Recovery time was similar for subsequent infections.

"Our study underscores the important role that vaccination against COVID has played, not just in reducing the severity of an infection but also in reducing the risk of long COVID," says Elizabeth C. Oelsner, the study's lead author and the Herbert Irving Associate Professor of Medicine.

Study details

The study involved over 4,700 participants from the Collaborative Cohort of Cohorts for COVID 19 Research(C4R), who were asked to report their time to recovery after infection with SARS-CoV-2.

The study found that, between 2020 and early 2023, the median recovery time after SARS-CoV2-infection was 20 days, and more than one in five adults did not recover within three months.

Women and adults with pre-pandemic cardiovascular disease were less likely to recover within three months. Other pre-pandemic health conditions -- including chronic kidney disease, diabetes, asthma, chronic lung disease, depressive symptoms, and a history of smoking -- were linked to longer recovery times, but these associations were no longer significant after accounting for sex, cardiovascular disease, vaccination, and variant exposure.

"Although studies have suggested that many patients with long COVID experience mental health challenges, we did not find that depressive symptoms prior to SARS-CoV-2 infection were a major risk factor for long COVID."

Other groups disproportionately affected by long COVID were American Indian and Alaska Native participants, in whom severe infections and longer recovery times were more common.

"Our study clearly establishes that long COVID posed a substantial personal and societal burden," says Oelsner. "By identifying who was likely to have experienced a lengthy recovery, we have a better understanding of who should be involved in ongoing studies of how to lessen or prevent the long-term effects of SARS-CoV-2 infection."

More information

The study is titled, "Epidemiologic Features of Recovery from SARS-CoV-2 Infection." It was published online June 17 in JAMA Network Open. The fill list of contributors and conflict of interest disclosures are available online.

Story Source:

Materials provided by Columbia University Irving Medical Center. Note: Content may be edited for style and length.

Journal Reference:

  1. Elizabeth C. Oelsner, Yifei Sun, Pallavi P. Balte, Norrina B. Allen, Howard Andrews, April Carson, Shelley A. Cole, Josef Coresh, David Couper, Mary Cushman, Martha Daviglus, Ryan T. Demmer, Mitchell S. V. Elkind, Linda C. Gallo, Jose D. Gutierrez, Virginia J. Howard, Carmen R. Isasi, Suzanne E. Judd, Alka M. Kanaya, Namratha R. Kandula, Robert C. Kaplan, Gregory L. Kinney, Anna M. Kucharska-Newton, Daniel T. Lackland, Joyce S. Lee, Barry J. Make, Yuan-I. Min, Joanne M. Murabito, Arnita F. Norwood, Victor E. Ortega, Kelley Pettee Gabriel, Bruce M. Psaty, Elizabeth A. Regan, Daniela Sotres-Alvarez, David Schwartz, James M. Shikany, Bharat Thyagarajan, Russell P. Tracy, Jason G. Umans, Ramachandran S. Vasan, Sally E. Wenzel, Prescott G. Woodruff, Vanessa Xanthakis, Ying Zhang, Wendy S. Post. Epidemiologic Features of Recovery From SARS-CoV-2 Infection. JAMA Network Open, 2024; 7 (6): e2417440 DOI: 10.1001/jamanetworkopen.2024.17440

Cite This Page:

Columbia University Irving Medical Center. "Risk factors for long COVID revealed." ScienceDaily. ScienceDaily, 17 June 2024. <>.
Columbia University Irving Medical Center. (2024, June 17). Risk factors for long COVID revealed. ScienceDaily. Retrieved July 17, 2024 from
Columbia University Irving Medical Center. "Risk factors for long COVID revealed." ScienceDaily. (accessed July 17, 2024).

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