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Circadian rhythm sleep disorder

Circadian rhythm sleep disorders are a family of sleep disorders affecting the timing of sleep. People with circadian rhythm sleep disorders are unable to sleep and wake at the times required for normal work, school, and social needs. They are generally able to get enough sleep if allowed to sleep and wake at the times dictated by their body clocks. Unless they have another sleep disorder, their sleep is of normal quality. Humans have biological rhythms, known as circadian rhythms, which are controlled by a biological clock and work on a daily time scale. Due to the circadian clock, sleepiness does not continuously increase as time passes. Instead, the drive for sleep follows a cycle, and the body is ready for sleep and for wakefulness at different times of the day.

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December 1, 2025

A high-speed “zap-and-freeze” method is giving scientists their clearest view yet of how brain cells send messages. By freezing tissue at the instant a signal fires, researchers revealed how synaptic vesicles behave in both mouse and human ...
Researchers found that repeated head impacts can disrupt a key system that helps the brain wash away waste. In professional fighters, this system initially seems to work harder after trauma, then declines over time. MRI scans revealed that these ...
Princeton researchers found that the brain excels at learning because it reuses modular “cognitive blocks” across many tasks. Monkeys switching between visual categorization challenges revealed that the prefrontal cortex assembles these blocks ...
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Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a ...
A massive veteran study found a strong connection between untreated sleep apnea and a higher chance of Parkinson’s. CPAP users had much lower odds of developing the condition. Researchers believe that repeated dips in oxygen during sleep may ...
Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called ...
Scientists discovered that more muscle and less hidden abdominal fat are linked to a younger biological brain age. Deep visceral fat appeared to accelerate brain aging, while muscle mass offered a protective ...
Scientists have found that a mutation tied to Alzheimer’s disrupts the production and quality of exosomes—tiny cell-made communication packets. Cells with the defective SORLA protein generate fewer exosomes and ones far less able to support ...
Hypertension begins harming the brain surprisingly early, even before measurable blood pressure increases. Key cells related to blood vessels, signaling, and myelin maintenance begin aging prematurely and malfunctioning. These disruptions resemble ...
Researchers have uncovered a surprising way the brain switches pain on, revealing that neurons can release an enzyme outside the cell that activates pain signals without disrupting normal movement or sensation. This enzyme, called VLK, modifies ...

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