Featured Research

from universities, journals, and other organizations

Yale Researchers Identify Molecule For Detecting Parasitic Infection In Humans

Date:
April 29, 2005
Source:
Yale University
Summary:
Researchers at Yale, in collaboration with NIH researchers, have identified a specific protein molecule that is used by the immune system for detection of parasitic infections, leading the way for development of future vaccines to combat these infections.

Researchers at Yale, in collaboration with NIH researchers, have identified a specific protein molecule that is used by the immune system for detection of parasitic infections, leading the way for development of future vaccines to combat these infections.

Related Articles


Published in the April 28 issue of Science Express, the study provides insight into understanding how infectious parasites interface with the immune system--a problem of great scientific and clinical importance.

Most infections are caused by bacterial or viral microorganisms that produce molecules quite different from those produced by humans and other eukaryotic organisms. When microorganisms infect humans, the atypical molecules are usually detected immediately by human proteins called Toll-like receptors (TLR) that alert the human immune system to fight the infection.

But parasites, like humans, are eukaryotic in origin and how the body detects them has been a mystery.

The common parasite Toxoplasma gondii (T. gondii) causing toxoplasmosis, has a complicated life cycle in which it is transmitted from mice to cats and then to humans. Previous research had shown that T. gondii is recognized by a TLR and that the recognition of this parasite is crucial for an appropriate immune response. However, it was unclear which of the 13 different TLRs present in mammals was responsible and which molecule of T. gondii was being recognized by the TLRs.

"In this study we found that the recognition of T. gondii by the innate immune system is mediated by a new member of the TLR family, TLR 11, that we discovered last year," said Sankar Ghosh, professor of immunobiology at Yale School of Medicine. "We further found that the specific recognition molecule was Toxoplasma profilin. The innate immune system has the capacity to recognize these proteins and the profilins are the triggers."

Ghosh said that although parasitic infections are less prominent in the United States than bacterial and viral infections, the global impact of parasitic infections on health is tremendous. "Insight obtained from these studies should lead to development of novel strategies to combat these infections," he said. "In particular, an understanding of the parasite components that trigger a host immune response may facilitate the development of better vaccines."

###

Other authors from Yale are Dekai Zhang, Matthew S. Hayden, Fayyaz S. Sutterwala and Richard A. Flavell.

The research was funded by National Institutes of Health.

Citation: Science Express (10.1126/science.1109893) (April 28, 2005).


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Yale Researchers Identify Molecule For Detecting Parasitic Infection In Humans." ScienceDaily. ScienceDaily, 29 April 2005. <www.sciencedaily.com/releases/2005/04/050428172051.htm>.
Yale University. (2005, April 29). Yale Researchers Identify Molecule For Detecting Parasitic Infection In Humans. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2005/04/050428172051.htm
Yale University. "Yale Researchers Identify Molecule For Detecting Parasitic Infection In Humans." ScienceDaily. www.sciencedaily.com/releases/2005/04/050428172051.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins