Featured Research

from universities, journals, and other organizations

Fitting In: Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool

Date:
October 4, 2005
Source:
Cold Spring Harbor Laboratory
Summary:
To determine the basis for the persistence of functional gene duplicates in the genome, scientists have collaborated on the largest systematic analysis of duplicated gene function to date. Using an integrative combination of computational and experimental approaches, they classified duplicate pairs of genes involved in yeast metabolism into four functional categories and found that each plays a substantial and important role in the maintenance of functional duplicates in the genome.

To determine the basis for the persistenceof functional gene duplicates in the genome, three scientists at theInstitute of Molecular Systems Biology at the Swiss Federal Instituteof Technology in Zόrich have collaborated on the largest systematicanalysis of duplicated gene function to date. Using an integrativecombination of computational and experimental approaches, theyclassified duplicate pairs of genes involved in yeast metabolism intofour functional categories: (1) back-up, where a duplicate gene copyhas acquired the ability to compensate in the absence of the othercopy, (2) subfunctionalization, where a duplicate copy has evolved acompletely new, non-overlapping function, (3) regulation, where thedifferential regulation of duplicates fine-tunes pathway usage, and (4)gene dosage, where the increased expression provided by the duplicategene copy augments production of the corresponding protein.

Theirresults, which appear in the October issue of the journal GenomeResearch, indicate that no single role prevails but that all four ofthe mechanisms play a substantial role in maintaining duplicate genesin the genome.

"Our results contradict other recent publicationsthat have focused on a single selective pressure as the basis for theretention of gene duplicates," explains Dr. Uwe Sauer, principalinvestigator on the project and Professor at the Institute of MolecularSystems Biology at the Swiss Federal Institute of Technology in Zόrich."We show that, at least for yeast metabolism, the persistence of theduplicated fraction of the genome can be better explained with an arrayof different, often overlapping functional roles."

Yeastmetabolism provides an ideal model for investigating the functionalbasis for gene duplication because a large proportion of genes involvedin this biological process have been duplicated. Of the 672 genesinvolved in yeast metabolism, 295 genes can be classified into 105families of duplicates. To put this into perspective, the yeast genomehas an estimated total of 6,000 genes, 1,500 of which are considered tobe duplicates. An ancient whole-genome duplication event is thought tobe responsible for the formation of many of these duplicate copies.

Sauer'sgroup demonstrated that of the 105 families of duplicated gene familiesinvolved in yeast metabolism, 34 demonstrated back-up function, 19 wereinvolved in increased gene dosage, 18 exhibited regulatory functions,and 18 had evolved new, more specialized functions. Therefore, each ofthese mechanisms plays a substantial and important role in themaintenance of functional duplicates in the gene pool.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Fitting In: Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool." ScienceDaily. ScienceDaily, 4 October 2005. <www.sciencedaily.com/releases/2005/10/051003233239.htm>.
Cold Spring Harbor Laboratory. (2005, October 4). Fitting In: Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/10/051003233239.htm
Cold Spring Harbor Laboratory. "Fitting In: Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool." ScienceDaily. www.sciencedaily.com/releases/2005/10/051003233239.htm (accessed July 23, 2014).

Share This




More Plants & Animals News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) — An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) — Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins