Featured Research

from universities, journals, and other organizations

Chronic Wasting Disease Is Transmissible Among Rodents

Date:
April 27, 2007
Source:
American Society for Microbiology
Summary:
For the first time, a new study demonstrates that certain rodents can be directly infected with chronic wasting disease and therefore serve as animal models for further study of the disease.

For the first time, a new study demonstrates that certain rodents can be directly infected with CWD and therefore serve as animal models for further study of the disease.

Chronic wasting disease (CWD), also known as mad cow disease in cattle and Creutzfeldt-Jacob disease in humans, is a transmissible prion disease most commonly found in deer and elk. Conversion of the normal host protein to an abnormal disease-associated form is an important part in the tracking of prion diseases and researchers are hopeful that rodent-adapted CWD models could assist in therapeutic development.

In the study transgenic and wild-type mice in addition to Syrian, Djungarian, Chinese, Siberian and Armenian hamsters were inoculated with CWD samples retrieved from deer and elk and monitored over various amounts of time. Distinct neuropathological patterns throughout differing incubation periods were observed in Chinese hamsters and transgenic mice offering the highest susceptibility rates. Wild-type mice and Djungarian hamsters were found not to be susceptible to CWD.

"We have shown that CWD from one or more cervid species can be transmitted to Sg, Chinese, Siberian, and Armenian hamsters and to Tg mice that express Sg hamster prion protein," say the researchers. "The resulting rodent-adapted CWD models could be useful in comparative studies of TSE strains in vivo as well as for testing potential anti-TSE therapeutic agents."

(G.J. Raymond, L.D. Raymond, K.D. Meade-White, A.G. Hughson, C. Favara, D. Gardner, E.S. Williams, M.W. Miller, R.E. Race, B. Caughey. 2007. Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. Journal of Virology, 81. 8: 4305-4314).


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Chronic Wasting Disease Is Transmissible Among Rodents." ScienceDaily. ScienceDaily, 27 April 2007. <www.sciencedaily.com/releases/2007/04/070426162107.htm>.
American Society for Microbiology. (2007, April 27). Chronic Wasting Disease Is Transmissible Among Rodents. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2007/04/070426162107.htm
American Society for Microbiology. "Chronic Wasting Disease Is Transmissible Among Rodents." ScienceDaily. www.sciencedaily.com/releases/2007/04/070426162107.htm (accessed August 22, 2014).

Share This




More Plants & Animals News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) — According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) — According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Ramen Health Risks: The Dark Side of the Noodle

Ramen Health Risks: The Dark Side of the Noodle

AP (Aug. 21, 2014) — South Koreans eat more instant ramen noodles per capita than anywhere else in the world. But American researchers say eating too much may increase the risk of diabetes, heart disease and stroke. (Aug. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins