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DNA Sensors Found To Be An Effective Artificial Nose

Date:
January 23, 2008
Source:
PLoS Biology
Summary:
Short sequences of solid-state DNA can selectively signal their interactions with small molecules in the vapor phase. These observations have been implemented in odor sensing in an electronic "nose" and further suggest that in vivo responses to small molecules may represent new, nongenetic attributes of DNA.

In designing artificial noses modeled after biological olfaction, the challenge has been to generate a similarly large sensor repertoire with the requisite combinatorial complexity to detect odors in the real world. A further requirement is that the sensors can be manufactured with exact chemical precision and reproducibility.

In a new study, Joel White, Mary AtKisson, John Kauer and colleagues demonstrate a previously unreported property of deoxyribonucleic acid. The researchers show that single-stranded DNA molecules tagged with a fluorescent reporter and dried onto solid surfaces can respond to vapor phase odor pulses in a sequence-selective manner.

In the context of detecting chemicals in either the aqueous or vapor phase, two general biological approaches have emerged. The first relies on individual, highly specific single receptors (sensors), each tuned to detect a single molecular species. Some examples include the receptors that mediate pheromone detection in insects, or those that function in neurotransmission.

The second approach, represented by the DNA sensors, is implemented by arrays of receptors with relatively broad responses. Here, specificity emerges from a constellation of receptor types that recognizes the molecule of interest. An example is the olfactory receptors in the main olfactory system of vertebrates.

This study not only highlights DNA's potential for use in a novel and powerful odor detection system, but it also highlights its potential to play other novel roles in vivo, for example as a small molecule receptor, well outside of its familiar one as the repository of information in the genome.

Citation: White J, Truesdell K, Williams LB, AtKisson MS, Kauer JS (2008) Solid-state, dye-labeled DNA detects volatile compounds in the vapor phase. PLoS Biol 6(1): e9. doi:10.1371/journal.pbio.0060009


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The above story is based on materials provided by PLoS Biology. Note: Materials may be edited for content and length.


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PLoS Biology. "DNA Sensors Found To Be An Effective Artificial Nose." ScienceDaily. ScienceDaily, 23 January 2008. <www.sciencedaily.com/releases/2008/01/080122203315.htm>.
PLoS Biology. (2008, January 23). DNA Sensors Found To Be An Effective Artificial Nose. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/01/080122203315.htm
PLoS Biology. "DNA Sensors Found To Be An Effective Artificial Nose." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122203315.htm (accessed July 23, 2014).

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