Featured Research

from universities, journals, and other organizations

How The Heart Takes Form: Early Heart Development In Vertebrates

Date:
February 12, 2008
Source:
Helmholtz Association
Summary:
Currently, one of the most important areas to explore in developmental biology is how cellular transformation processes lead to the three-dimensional formation of organs. A better understanding of these processes is a basic requirement for elucidating congenital malformation of organs. Researchers have detailed how the heart develops in the embryo from a flat disc, the so-called heart field. The tissue of this two-dimensional structure consists of a thin layer of epithelial cells. Similar cells line all inner organs, but also the skin and blood vessels.

Heart formation in the zebrafish: Transition of the flat, disc-shaped heart field into the primary linear heart tube, which then evolves into a multi-chamber, hollow organ.
Credit: Graphics: Stefan Rohr/Copyright: MDC

For the first time, scientists have described the transition of the flat, disc-shaped heart field into the primary linear heart tube. The investigations on zebrafish embryos were made by Stefan Rohr and Cécile Otten, members of the research group of Dr. Salim Abdelilah-Seyfried of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany.

Currently, one of the most important areas to explore in developmental biology is how cellular transformation processes lead to the three-dimensional formation (morphogenesis) of organs. A better understanding of these processes is a basic requirement for elucidating congenital malformation of organs.

The heart, for instance, develops in the embryo from a flat disc, the so-called heart field. The tissue of this two-dimensional structure consists of a thin layer of epithelial cells. Similar cells line all inner organs, but also the skin and blood vessels.

Which cellular processes drive the formation of the three-dimensional heart tube that then evolves into a multi-chamber, hollow organ? Do individual cells migrate and form this hollow structure by fusing with other cells or does the whole heart field change its form? Until now, all of these were open questions in developmental biology.

Stefan Rohr, PhD student with Dr. Abdelilah-Seyfried, used zebrafish (Latin: Danio rerio) for his investigations because their embryos are transparent, allowing researchers to observe each cell of the living organism under the microscope. That is why these vertebrates are particularly interesting for developmental biologists.

Surprisingly, the cells of the right and left heart fields behave very differently, as Stefan Rohr was able to demonstrate. The cells of the right heart field form a kind of lip which, as a group, migrates underneath the cells of the left heart field, thereby “involuting” or turning on its own axis once again. This complex inversion of the right heart field generates the ventral floor, whereas the noninvoluting left heart field gives rise to the future roof of the heart tube.

This process is steered by various genes, which also regulate the right/left asymmetry of vertebrates. When the researchers switched off one of these genes, the cells often migrated in the wrong direction and the lip was formed in the wrong place.

Related Articles


The research study, Asymmetric Involution of the Myocardial Field Drives Heart Tube Formation in Zebrafish, has just been published by  Stefan Rohr, Cécile Otten and Salim Abdelilah-Seyfried in the online edition of Circulation Research.


Story Source:

The above story is based on materials provided by Helmholtz Association. Note: Materials may be edited for content and length.


Cite This Page:

Helmholtz Association. "How The Heart Takes Form: Early Heart Development In Vertebrates." ScienceDaily. ScienceDaily, 12 February 2008. <www.sciencedaily.com/releases/2008/02/080206153309.htm>.
Helmholtz Association. (2008, February 12). How The Heart Takes Form: Early Heart Development In Vertebrates. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2008/02/080206153309.htm
Helmholtz Association. "How The Heart Takes Form: Early Heart Development In Vertebrates." ScienceDaily. www.sciencedaily.com/releases/2008/02/080206153309.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gorilla Falls Into Zoo Moat

Gorilla Falls Into Zoo Moat

Reuters - Light News Video Online (Mar. 31, 2015) — A gorilla comes to the rescue of her sister who fell into a moat in Israel&apos;s Safari zoo. Rough cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
California on Alert Over Surge in Sea Lion Strandings

California on Alert Over Surge in Sea Lion Strandings

AFP (Mar. 31, 2015) — Since the start of the year, thousands of baby sea lions have washed up on beaches along the west coast of the United States. Marine animal care centers are working around the clock to save the stranded creatures. Duration: 02:06 Video provided by AFP
Powered by NewsLook.com
Giant Amphibian Fossils Found in Portugal

Giant Amphibian Fossils Found in Portugal

Reuters - Light News Video Online (Mar. 31, 2015) — Scientists discover a new species of giant amphibian that was one of the largest predators on earth about 220 million year ago. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Rhino Goes on Deadly Rampage in Nepal

Rhino Goes on Deadly Rampage in Nepal

Reuters - News Video Online (Mar. 31, 2015) — A rhino runs rampant down a bustling city street, killing one woman and injuring several others, before security personnel chase it back into the forest. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins