Featured Research

from universities, journals, and other organizations

Transgenic Mice Don't Mind Cold Weather

Date:
March 16, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Overexpressing a protein involved in the uptake of fat in muscle of mice can improve their tolerance to cold temperatures, reports a new study that showcases the over-looked role muscle may play in the cold response. When temperatures drop, mammals respond by generating heat (thermogenesis), through mechanisms like shivering and breaking down 'brown fat' (high energy fat cells that are especially prominent in newborns and hibernating animals).

Overexpressing a protein involved in the uptake of fat in muscle of mice can improve their tolerance to cold temperatures, researchers find in a new study that showcases the over-looked role muscle may play in the cold response.

When temperatures drop, mammals respond by generating heat (thermogenesis), through mechanisms like shivering and breaking down 'brown fat' (high energy fat cells that are especially prominent in newborns and hibernating animals).

Considering that muscle accounts for over one-third of body mass and muscle activity regulates fat metabolism, Dalan Jensen and colleagues found that increasing the muscle's ability to use fat for energy had a profound impact on its contribution to thermogenesis.

They generated mice overexpressing lipoprotein lipase (LPL), an enzyme that extracts fat from the blood so that it can be used to produce energy instead of sugar. They placed LPL mice in a chamber set to 4 C (39 F) and found that they were far more cold tolerant than regular mice; LPL mice could withstand 4 C for several hours and still maintain normal body temperatures.

This tolerance came from LPL's ability to increase the muscle's ability to oxidize fat, which allow LPL mice to produce more heat than regular animals without increasing their physical activity. Interestingly, this enhanced muscular thermogenesis is akin to how birds --which lack brown fat--produce heat and suggests that mammals, too, have multiple avenues to try and stay warm.

This research was recently published in The Journal Of Lipid Research.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Transgenic Mice Don't Mind Cold Weather." ScienceDaily. ScienceDaily, 16 March 2008. <www.sciencedaily.com/releases/2008/03/080314160218.htm>.
American Society for Biochemistry and Molecular Biology. (2008, March 16). Transgenic Mice Don't Mind Cold Weather. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/03/080314160218.htm
American Society for Biochemistry and Molecular Biology. "Transgenic Mice Don't Mind Cold Weather." ScienceDaily. www.sciencedaily.com/releases/2008/03/080314160218.htm (accessed April 17, 2014).

Share This



More Plants & Animals News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Raw: Three Rare White Tiger Cubs Debut at Zoo

Raw: Three Rare White Tiger Cubs Debut at Zoo

AP (Apr. 16, 2014) The Buenos Aires Zoo debuted a trio of rare white Bengal tiger cubs on Wednesday. (April 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins