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Real-time Observation Of DNA-repair Mechanism

Date:
May 25, 2008
Source:
Delft University of Technology
Summary:
For the first time, researchers have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells.
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Researchers have witnessed the spontaneous repair of damage to DNA molecules in real time.
Credit: Image courtesy of Delft University of Technology

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells.

Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the journal Molecular Cell.

Cells have mechanisms for repairing the continuous accidental damage occurring in DNA. These damages can vary from a change to a single part of the DNA to a total break in the DNA structure. These breaks can, for instance, be caused by ultraviolet light or X-rays, but also occur during cell division, when DNA molecules split and form two new DNA molecules. If this type of break is not properly repaired it can be highly dangerous to the functioning of the cell and lead to the creation of a cancerous cell.

One major DNA-repair mechanism involved in repairing these breaks is known as homologous recombination. This mechanism has been observed for the first time by Delft University of Technology researchers in real time and at the level of a single DNA molecule.

To observe this, a DNA molecule is stretched between a magnetic bead and a glass surface. A force is exerted on the magnetic bead using a magnetic field, enabling researchers to pull and rotate a single DNA molecule in a controlled fashion. As the position of the bead changes when the DNA molecule is repaired, researchers are able to observe the repair process in detail.


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The above story is based on materials provided by Delft University of Technology. Note: Materials may be edited for content and length.


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Delft University of Technology. "Real-time Observation Of DNA-repair Mechanism." ScienceDaily. ScienceDaily, 25 May 2008. <www.sciencedaily.com/releases/2008/05/080522120610.htm>.
Delft University of Technology. (2008, May 25). Real-time Observation Of DNA-repair Mechanism. ScienceDaily. Retrieved May 29, 2015 from www.sciencedaily.com/releases/2008/05/080522120610.htm
Delft University of Technology. "Real-time Observation Of DNA-repair Mechanism." ScienceDaily. www.sciencedaily.com/releases/2008/05/080522120610.htm (accessed May 29, 2015).

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