Featured Research

from universities, journals, and other organizations

Breakthrough In Plant Medicine Production

Date:
June 27, 2008
Source:
Wageningen University and Research Centre
Summary:
Researchers have succeeded in further unraveling and manipulating the glycosylation of proteins in plants. The scientists expect that this knowledge will allow plants to be applied more often in the production of therapeutic proteins, an important type of medicine.

A research team of scientists from Wageningen University and Research Centre in the Netherlands has succeeded in further unravelling and manipulating the glycosylation of proteins in plants. The scientists expect that this knowledge will allow plants to be applied more often in the production of therapeutic proteins, an important type of medicine.

Related Articles


The discovery fits in with technology developed by the Wageningen UR research institute Plant Research International for the production of biopharmaceuticals in plants.

Proteins in plants, animals and people are equipped with various sugar chains in a process known as glycosylation. The sugar chains are of significance to the functioning of many proteins. Moreover, their identity and uniformity is crucial to the quality of therapeutic proteins.

The glycosylation of proteins in plants, people and animals basically consists of three stages. Initially sugar chains are constructed, which then attach to the protein in specific locations. Finally, the sugar chains are further modified as specific sugars are attached to the chain.

“We are the first institute in the world to identify a gene in plants that is involved in the construction of these sugar chains, the first stage in glycosylation,” says scientist Maurice Henquet. “It seems that the chains become increasingly uniform as the expression of this gene is reduced.” One type of chain, a relatively simple one, is mainly developed. The sugar chains which are attached to the proteins are therefore a better starting point for making adjustments that are designed to optimise the biological function as medicine.

“From now on we will be able to improve the manipulation of glycosylation,” Henquet continues. “And plants will become even more suitable for medicine production.”


Story Source:

The above story is based on materials provided by Wageningen University and Research Centre. Note: Materials may be edited for content and length.


Journal Reference:

  1. Henquet et al. Identification of the Gene Encoding the 1,3-Mannosyltransferase (ALG3) in Arabidopsis and Characterization of Downstream N-Glycan Processing. The Plant Cell Online, 2008; DOI: 10.1105/tpc.108.060731

Cite This Page:

Wageningen University and Research Centre. "Breakthrough In Plant Medicine Production." ScienceDaily. ScienceDaily, 27 June 2008. <www.sciencedaily.com/releases/2008/06/080625091640.htm>.
Wageningen University and Research Centre. (2008, June 27). Breakthrough In Plant Medicine Production. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/06/080625091640.htm
Wageningen University and Research Centre. "Breakthrough In Plant Medicine Production." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625091640.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins