Featured Research

from universities, journals, and other organizations

New Vaccine Protects Monkeys From Pneumonic Plague

Date:
December 21, 2008
Source:
American Society for Microbiology
Summary:
Scientists have developed a vaccine incorporating the protein V10 and found that it protected macaques from lethal pneumonic plague and may have implications for use in humans.

In a new study researchers from the University of Chicago, Illinois and the Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico developed a vaccine incorporating the protein V10 and found that it protected macaques from lethal pneumonic plague and may have implications for use in humans.

Related Articles


Yersinia pestis is the causative agent of pneumonic plague infections in humans. Recent wildlife studies indicate that plague is rampant among rodent populations in the southwestern United States, Southeast Asia, Eastern Europe, central and southern Africa as well as South America where humans are highly susceptible to infection. The potential for large-scale human infections as well as continuously emerging antibiotic-resistant strains of Y. pestis reinforces the need for an effective vaccine.

Currently, antiplague subunit vaccines in development for human use contain recombinant low-calcium-response V antigens (rLcrV) and recombinant F1 (rF1) antigens either in equal amounts or as a fusion protein (rF1-rLcrV). In the study the researchers immunized cynomolgus macaques with an aerosol vaccine incorporating a variant of the rLcrV protein, recombinant V10 (rV10) and challenged them with a lethal dose of pneumonic plague. Results showed that rV10 prevented infection and displayed equally protective immunity to vaccines containing rLcrV or rLcrV plus rF1. Further studies showed that some antibodies of macaques immunized with rLcrV, rV10, or rF1, either alone or in combination, conferred protection in mice challenged with bubonic plague.

"Here, we show that immunization with either purified rLerV (a protein at the tip of type III needles) or a variant of this protein, recombinant V10 (rV10) (lacking amino acid residues 271 to 300), alone or in combination with rF1, prevented pneumonic lesions and disease pathogenesis," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. C.A. Cornelius, L.E. Quenee, K.A. Overheim, F. Koster, T.L. Brasel, D. Elli, N.A. Ciletti, O. Schneewind. Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague. Infection and Immunity,. Infection and Immunity, 76. 12: 5588-5597

Cite This Page:

American Society for Microbiology. "New Vaccine Protects Monkeys From Pneumonic Plague." ScienceDaily. ScienceDaily, 21 December 2008. <www.sciencedaily.com/releases/2008/12/081219093756.htm>.
American Society for Microbiology. (2008, December 21). New Vaccine Protects Monkeys From Pneumonic Plague. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/12/081219093756.htm
American Society for Microbiology. "New Vaccine Protects Monkeys From Pneumonic Plague." ScienceDaily. www.sciencedaily.com/releases/2008/12/081219093756.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins