Featured Research

from universities, journals, and other organizations

New Vaccine Protects Monkeys From Pneumonic Plague

Date:
December 21, 2008
Source:
American Society for Microbiology
Summary:
Scientists have developed a vaccine incorporating the protein V10 and found that it protected macaques from lethal pneumonic plague and may have implications for use in humans. 

In a new study researchers from the University of Chicago, Illinois and the Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico developed a vaccine incorporating the protein V10 and found that it protected macaques from lethal pneumonic plague and may have implications for use in humans. 

Related Articles


Yersinia pestis is the causative agent of pneumonic plague infections in humans. Recent wildlife studies indicate that plague is rampant among rodent populations in the southwestern United States, Southeast Asia, Eastern Europe, central and southern Africa as well as South America where humans are highly susceptible to infection. The potential for large-scale human infections as well as continuously emerging antibiotic-resistant strains of Y. pestis reinforces the need for an effective vaccine.

Currently, antiplague subunit vaccines in development for human use contain recombinant low-calcium-response V antigens (rLcrV) and recombinant F1 (rF1) antigens either in equal amounts or as a fusion protein (rF1-rLcrV). In the study the researchers immunized cynomolgus macaques with an aerosol vaccine incorporating a variant of the rLcrV protein, recombinant V10 (rV10) and challenged them with a lethal dose of pneumonic plague. Results showed that rV10 prevented infection and displayed equally protective immunity to vaccines containing rLcrV or rLcrV plus rF1. Further studies showed that some antibodies of macaques immunized with rLcrV, rV10, or rF1, either alone or in combination, conferred protection in mice challenged with bubonic plague.

"Here, we show that immunization with either purified rLerV (a protein at the tip of type III needles) or a variant of this protein, recombinant V10 (rV10) (lacking amino acid residues 271 to 300), alone or in combination with rF1, prevented pneumonic lesions and disease pathogenesis," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. C.A. Cornelius, L.E. Quenee, K.A. Overheim, F. Koster, T.L. Brasel, D. Elli, N.A. Ciletti, O. Schneewind. Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague. Infection and Immunity,. Infection and Immunity, 76. 12: 5588-5597

Cite This Page:

American Society for Microbiology. "New Vaccine Protects Monkeys From Pneumonic Plague." ScienceDaily. ScienceDaily, 21 December 2008. <www.sciencedaily.com/releases/2008/12/081219093756.htm>.
American Society for Microbiology. (2008, December 21). New Vaccine Protects Monkeys From Pneumonic Plague. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/12/081219093756.htm
American Society for Microbiology. "New Vaccine Protects Monkeys From Pneumonic Plague." ScienceDaily. www.sciencedaily.com/releases/2008/12/081219093756.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins