Featured Research

from universities, journals, and other organizations

Geneticist reveals molecular view of key epigenetic regulator

Date:
December 15, 2009
Source:
University of British Columbia
Summary:
New research reveals the structure and function of a key player in regulating chromatin in yeast and humans.

In a paper published in the journal Proceedings of the National Academy of Sciences, Dr. Michael Kobor's laboratory reported the structure and function of a key player in regulating chromatin in yeast and humans. Chromatin, a dynamic DNA-protein complex, is involved in numerous cellular processes and has profound effects on human health and disease.

The study is a major advancement in elucidating the role and structure of an epigenetic regulator commonly involved in human leukemia and other human diseases.

Chromatin biology is central to epigenetics, which is a framework for environmental regulation of genome function. The chromatin regulator Yaf9 contains a module called the YEATS domain, which is found in many other proteins implicated in chromatin regulation and cancer. The molecular structure and function of YEATS domain proteins has been an unresolved mystery in the field of epigenetics. Using advanced X-ray crystallography, the team gained the first detailed picture at atomic resolution of the YEATS domain.

Furthermore, the authors showed that its function is conserved from yeast to human, and revealed a requirement of the YEATS domain for two different mechanisms by which chromatin can be modified.

Alice Wang and Julia Schulze, two PhD candidates in Dr. Kobor's laboratory, performed this work in collaboration with researchers at the University of California, Berkeley.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University of British Columbia. "Geneticist reveals molecular view of key epigenetic regulator." ScienceDaily. ScienceDaily, 15 December 2009. <www.sciencedaily.com/releases/2009/12/091209134910.htm>.
University of British Columbia. (2009, December 15). Geneticist reveals molecular view of key epigenetic regulator. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/12/091209134910.htm
University of British Columbia. "Geneticist reveals molecular view of key epigenetic regulator." ScienceDaily. www.sciencedaily.com/releases/2009/12/091209134910.htm (accessed September 20, 2014).

Share This



More Plants & Animals News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins