Featured Research

from universities, journals, and other organizations

Studies shed new light on early transmembrane signaling

Date:
January 25, 2010
Source:
Rockefeller University Press
Summary:
Two new studies further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels.

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels.

The studies appear online January 25 in the Journal of General Physiology.

Falkenburger et al. take advantage of recent progress in fluorescence technology -- which allows for analysis of biochemical events in single living cells -- to perform a systematic analysis of the PLC signal transmission process.

According to Tamas Balla (National Institutes of Health) in a Commentary accompanying the articles, the new studies extend the kinetic model of the signaling cascade to cover the entire process, from the activation of the M1 muscarinic receptors to the regulation of the potassium channels. Specifically, Falkenburger et al. show the steps that link changes in PtdIns(4,5)P2 -- an important plasma membrane regulatory lipid -- to changes in KCNQ potassium channel activity.

Journal references:

Balla, T. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910396.

Falkenburger, B.H., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910344.

Falkenburger, B.H., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910345.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "Studies shed new light on early transmembrane signaling." ScienceDaily. ScienceDaily, 25 January 2010. <www.sciencedaily.com/releases/2010/01/100125094507.htm>.
Rockefeller University Press. (2010, January 25). Studies shed new light on early transmembrane signaling. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2010/01/100125094507.htm
Rockefeller University Press. "Studies shed new light on early transmembrane signaling." ScienceDaily. www.sciencedaily.com/releases/2010/01/100125094507.htm (accessed September 16, 2014).

Share This



More Plants & Animals News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Conservationists Face Uphill PR Battle With New Shark Rules

Conservationists Face Uphill PR Battle With New Shark Rules

Newsy (Sep. 14, 2014) New conservation measures for shark fishing face an uphill PR battle in the fight to slow shark extinction. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Lion Cubs the Pride of San Diego Zoo

Lion Cubs the Pride of San Diego Zoo

Reuters - US Online Video (Sep. 13, 2014) Roars of excitement as a proud lioness shows off her four cubs at the San Diego Zoo Safari Park. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins