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Variations on the genetic theme: Researchers present global map of human gene expression

Date:
April 8, 2010
Source:
European Molecular Biology Laboratory
Summary:
Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialized properties. By integrating gene expression data from an unprecedented variety of human tissue samples, researchers have for the first time produced a global map of gene expression.

This image shows the 5,372 samples as dots colour-coded for the six major clusters identified by comparing gene expression profiles. The left and right panels of the figure are projections of the same three-dimensional shape viewed from two different perspectives.
Credit: Brazma / EMBL

Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties.

By integrating gene expression data from an unprecedented variety of human tissue samples, Alvis Brazma and his team at the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory (EMBL), and their collaborators have for the first time produced a global map of gene expression. The full analysis behind this unique view of the genetic activities determining our appearance, function and behaviour is published in Nature Biotechnology.

The analysis used data collected from 163 laboratories worldwide involving 5,372 human samples from various tissues, cell types and diseases. Most transcriptomics experiments compare gene expression in only a few cell types or conditions and although technically challenging, integrating this data on a large-scale has created a new way for scientists to explore gene expression. The analysis is visualised as a map subdividing the human gene expression space into six distinct major groups or 'continents'.

The continents emerged by grouping samples with similar gene expression signatures. This established the identity of the six groups: brain; muscle; hematopoietic (blood related); healthy and tumour solid tissues; cell lines derived from solid tissues; and partially differentiated cells. By visualising these subsets in 3D, comparisons can be made on the degree of similarity in the gene expression profiles on each grouping. For example, analysis of the continents showed that cell lines are usually more similar to each other than to their tissue of origin.

A new bioinformatics service allowing anyone to explore this expression map has been developed by the European Bioinformatics Institute as part of the ArrayExpress Gene Expression Atlas resource (www.ebi.ac.uk/gxa/).


Story Source:

The above story is based on materials provided by European Molecular Biology Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Margus Lukk, Misha Kapushesky, Janne Nikkilä, Helen Parkinson, Angela Goncalves, Wolfgang Huber, Esko Ukkonen, Alvis Brazma. A global map of human gene expression. Nature Biotechnology, 8 April 2010 DOI: 10.1038/nbt0410-322

Cite This Page:

European Molecular Biology Laboratory. "Variations on the genetic theme: Researchers present global map of human gene expression." ScienceDaily. ScienceDaily, 8 April 2010. <www.sciencedaily.com/releases/2010/04/100408105154.htm>.
European Molecular Biology Laboratory. (2010, April 8). Variations on the genetic theme: Researchers present global map of human gene expression. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/04/100408105154.htm
European Molecular Biology Laboratory. "Variations on the genetic theme: Researchers present global map of human gene expression." ScienceDaily. www.sciencedaily.com/releases/2010/04/100408105154.htm (accessed September 17, 2014).

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