Featured Research

from universities, journals, and other organizations

Antibody may help treat and prevent influenza outbreaks

Date:
July 10, 2010
Source:
Public Library of Science
Summary:
Researchers have discovered a monoclonal antibody that is effective against "avian" H5N1, seasonal H1N1 and the 2009 "swine" H1N1 influenza. Scientists have shown that this antibody potently prevents and treats the swine H1N1 influenza in mouse models of the disease.

Researchers have discovered a monoclonal antibody that is effective against "Avian" H5N1, seasonal H1N1 and the 2009 "Swine" H1N1 influenza. Scientists at Sea Lane Biotechnologies, LLC, in collaboration with Mt. Sinai School of Medicine, St. Jude Research Hospital and the Scripps Research Institute, have shown that this antibody potently prevents and treats the Swine H1N1 influenza in mouse models of the disease.

Related Articles


Results are published July 8 in the open-access journal PLoS Pathogens.

Previous work on this antibody, A06, demonstrated "first in class" activity against the evolutionarily distant Avian H5N1 and seasonal H1N1 influenzas. The authors believe that the antibody targets a conserved region of the viral coat protein, hemagluttinin, accounting for the extended breadth of activity against multiple, genetically distinct strains.

In this study, the authors isolated A06 from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection. They demonstrate that the antibody is effective against 2009 pandemic influenza in a cell culture assay and also in mouse models of disease when given before and after lethal influenza infection.

In late 2009, the WHO declared the first influenza pandemic in 40 years due to the 2009 "Swine" H1N1 influenza virus which swept the globe. Fortunately, the Swine influenza proved to be mild. The pandemic did, however, point out the weaknesses in the current treatment options available to stop a more virulent pandemic. Vaccines take months to prepare and many strains of influenza are already resistant to small molecule treatments like Tamiflu. Antibodies, like A06, could provide a significant line of defense against a more serious pandemic threat and contribute to efforts to create a universal vaccine.

This study demonstrates the therapeutic potential of monoclonal antibodies to protect and treat influenza. While the study was limited to mice, the activity is reflective of the potential benefit to humans. Anti-influenza antibody therapeutics could help to fill the current gap in the existing arsenal of treatments against influenza and could, one day, help to contain a deadly pandemic, according to the authors.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kashyap AK, Steel J, Rubrum A, Estelles A, Briante R, et al. Protection from the 2009 H1N1 Pandemic Influenza by an Antibody from Combinatorial Survivor-Based Libraries. PLoS Pathogens, 2010; 6 (7): e1000990 DOI: 10.1371/journal.ppat.1000990

Cite This Page:

Public Library of Science. "Antibody may help treat and prevent influenza outbreaks." ScienceDaily. ScienceDaily, 10 July 2010. <www.sciencedaily.com/releases/2010/07/100708171343.htm>.
Public Library of Science. (2010, July 10). Antibody may help treat and prevent influenza outbreaks. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/07/100708171343.htm
Public Library of Science. "Antibody may help treat and prevent influenza outbreaks." ScienceDaily. www.sciencedaily.com/releases/2010/07/100708171343.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins