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Exposure to low doses of BPA alters gene expression in the fetal mouse ovary

Date:
August 28, 2010
Source:
Society for the Study of Reproduction
Summary:
A new study finds that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

A new study published online in the journal Biology of Reproduction finds that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

Bisphenol A (BPA) is a chemical used in plastics for making some baby and water bottles, linings of food and beverage cans, and other human consumer products.

The mice in this study were given BPA at doses thought to be equivalent to levels currently being experienced by humans.

The research, conducted in the laboratory of Dr. Patricia A. Hunt at Washington State University (WSU) in Pullman, showed that BPA exposure affects the earliest stages of egg production in the ovaries of the developing mouse fetuses, thus suggesting that the next generation (the grandchildren of the females given BPA) may suffer genetic defects in such biological processes as mitosis and DNA replication.

In addition, the WSU research team noted that their study "revealed a striking down-regulation of mitotic/cell cycle genes, raising the possibility that BPA exposure immediately before meiotic entry might act to shorten the reproductive lifespan of the female" by reducing the total pool of fetal oocytes.

Future studies in Dr. Hunt's laboratory will focus on genetic changes produced over a range of BPA exposure.


Story Source:

The above story is based on materials provided by Society for the Study of Reproduction. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Lawson, M. Gieske, B. Murdoch, P. Ye, Y. Li, T. Hassold, P. A. Hunt. Gene Expression in the Fetal Mouse Ovary Is Altered by Exposure to Low Doses of Bisphenol A. Biology of Reproduction, 2010; DOI: 10.1095/biolreprod.110.084814

Cite This Page:

Society for the Study of Reproduction. "Exposure to low doses of BPA alters gene expression in the fetal mouse ovary." ScienceDaily. ScienceDaily, 28 August 2010. <www.sciencedaily.com/releases/2010/08/100825093249.htm>.
Society for the Study of Reproduction. (2010, August 28). Exposure to low doses of BPA alters gene expression in the fetal mouse ovary. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/08/100825093249.htm
Society for the Study of Reproduction. "Exposure to low doses of BPA alters gene expression in the fetal mouse ovary." ScienceDaily. www.sciencedaily.com/releases/2010/08/100825093249.htm (accessed July 31, 2014).

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