Featured Research

from universities, journals, and other organizations

Structural details of a key protein for cellular signal transduction

Date:
September 10, 2010
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
Scientists in Germany have succeeded in elucidating the structure of an important region of the Sam68 protein. Sam68 is a key protein for cellular signal transduction.

Details of the structure of the Sam68 protein.
Credit: Helge Meyer, Helmholtz Zentrum München and Technische Universität München

Scientists of the Institute of Structural Biology of Helmholtz Zentrum München and the Technische Universität München have succeeded in elucidating the structure of an important region of the Sam68 protein. Sam68 is a key protein for cellular signal transduction.

Related Articles


The Journal of Biological Chemistry has selected the report of these research findings as one of two "papers of the week" for its September 10, 2010 issue and has chosen the structural model as cover image.

Using NMR spectroscopy, Professor Michael Sattler and his team elucidated the spatial structure of the Qua1 region of Sam68, which is responsible for the dimerization of the protein. In collaboration with the research group of Professor Ruth Brack-Werner of the Institute of Virology, the authors showed that this region is essential for the biological function of Sam68. The image reveals an unusual spatial structure, in which two helices of respectively one Qua1 region (green and blue) interact with each other and mediate the dimerization of Qua1 and thus of Sam68.

Sam68 belongs to the family of STAR proteins which carry out important tasks in the signal-regulated processing of genetic information and its translation into protein. Among others, Sam68 regulates specific processes linked to the cell cycle and apoptosis and plays a key role in the pathogenesis of cancer.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. H. Meyer, K. Tripsianes, M. Vincendeau, T. Madl, F. Kateb, R. Brack-Werner, M. Sattler. Structural Basis for Homodimerization of the Src-associated during Mitosis, 68-kDa Protein (Sam68) Qua1 Domain. Journal of Biological Chemistry, 2010; 285 (37): 28893 DOI: 10.1074/jbc.M110.126185

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Structural details of a key protein for cellular signal transduction." ScienceDaily. ScienceDaily, 10 September 2010. <www.sciencedaily.com/releases/2010/09/100910083350.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2010, September 10). Structural details of a key protein for cellular signal transduction. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2010/09/100910083350.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Structural details of a key protein for cellular signal transduction." ScienceDaily. www.sciencedaily.com/releases/2010/09/100910083350.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Tourists Visit Rare Grey Whales in Mexico

Raw: Tourists Visit Rare Grey Whales in Mexico

AP (Mar. 4, 2015) — Once nearly extinct, grey whales now migrate in their thousands to Mexico&apos;s Vizcaino reserve in Baja California, in search of warmer waters to mate and give birth. Tourists flock to the reserve to see the whales, measuring up to 49 feet long. (March 4) Video provided by AP
Powered by NewsLook.com
Australian Museum Shares Terrifying Goblin Shark With the World

Australian Museum Shares Terrifying Goblin Shark With the World

Buzz60 (Mar. 4, 2015) — The Australian Museum has taken in its fourth-ever goblin shark, a rare fish with an electricity-sensing snout and &apos;alien-like&apos; jaw. Mike Janela (@mikejanela) takes a look. Video provided by Buzz60
Powered by NewsLook.com
Prince William Calls for Unified Effort Against Illegal Wildlife Trade

Prince William Calls for Unified Effort Against Illegal Wildlife Trade

Reuters - Entertainment Video Online (Mar. 4, 2015) — Britain&apos;s Prince William pledges to unite against illegal wildlife trade on the final day of his visit to China. Rough cut - no reporter narration Video provided by Reuters
Powered by NewsLook.com
Rare Goblin Shark Found in Australia

Rare Goblin Shark Found in Australia

AFP (Mar. 3, 2015) — A goblin shark, a rare sea creature described as an &apos;alien of the deep&apos; is found off Australia and delivered to the Australian Museum in Sydney. Duration: 01:25 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins