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New method for studying molecules discovered

Date:
November 18, 2010
Source:
Queen's University
Summary:
Researchers have discovered the method for studying oxygen in large molecular systems. The findings will help in the study of proteins, DNA, RNA and other molecular structures.

Queen's professor Gang Wu at the National Ultrahigh-Field NMR Facility for Solids in Ottawa.
Credit: Image courtesy of Queen's University

Researchers at Queen's University have discovered the method for studying oxygen in large molecular systems. The findings will help in the study of proteins, DNA, RNA and other molecular structures.

Biological molecules make up all living creatures on earth and contain four major elements -- hydrogen, carbon, nitrogen and oxygen. But until now scientists were only able to use nuclear magnetic resonance (NMR) to study three out of the four elements in the molecule puzzle because oxygen wavelengths were difficult to detect.

"Oxygen signals were so weak, so to speak, that no one could make use of them," says chemistry professor Gang Wu. "Now there is a way of detecting them even in complex biomolecular systems."

Dr. Wu and his colleagues used one of the strongest NMR spectrometers in the world, located at the National Ultrahigh-Field NMR Facility for Solids in Ottawa, to create a magnetic field in which oxygen's wavelength could be detected. They also enriched the oxygen in the molecule using isotope enrichment, and implemented new NMR techniques to boost the sensitivity for detecting weak signals.

The result is an amplified oxygen wavelength that can be studied. Scientists can now examine all four major elements and learn more about the chemical structure and interaction of large molecules.

Dr. Wu's colleagues include lead author and Queen's post-doctoral fellow Jianfeng Zhu, Eric Ye (University of Ottawa) and Victor Terskikh (NRC Steacie Institute for Molecular Sciences).

The findings were recently featured as a cover article in Angewandte Chemie.


Story Source:

The above story is based on materials provided by Queen's University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jianfeng Zhu, Eric Ye, Victor Terskikh, Gang Wu. Inside Cover: Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes (Angew. Chem. Int. Ed. 45/2010). Angewandte Chemie International Edition, 2010; 49 (45): 8278 DOI: 10.1002/anie.201004202

Cite This Page:

Queen's University. "New method for studying molecules discovered." ScienceDaily. ScienceDaily, 18 November 2010. <www.sciencedaily.com/releases/2010/11/101117184455.htm>.
Queen's University. (2010, November 18). New method for studying molecules discovered. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/11/101117184455.htm
Queen's University. "New method for studying molecules discovered." ScienceDaily. www.sciencedaily.com/releases/2010/11/101117184455.htm (accessed April 20, 2014).

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