Featured Research

from universities, journals, and other organizations

No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals

Date:
December 14, 2010
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Phenylketonuria is the most common metabolic disease in humans. It occurs when the so-called PAH gene is defective, thus preventing the amino acid phenylalanine from being metabolized to the amino acid tyrosine. This leads to an accumulation of phenylalanine and to severe developmental disorders. Researchers now report that the PAH gene is not only present in animals and humans, but also in algae, mosses, and coniferous trees.

Phenylketonuria is the most common metabolic disease in humans. It occurs when the so-called PAH gene is defective, thus preventing the amino acid phenylalanine from being metabolized to the amino acid tyrosine. This leads to an accumulation of phenylalanine and to severe developmental disorders.

Related Articles


In the current issue of the journal Plant Cell, an international research team at the University of Florida, the CNRS Institute in Grenoble, the Noble Foundation, and the University of Freiburg now reports that the PAH gene is not only present in animals and humans, but also in algae, mosses, and coniferous trees. The scientists have not yet succeeded in discovering this gene in flowering plants.

The biologists in Freiburg, led by Prof. Dr. Ralf Reski, switched off the PAH gene in the moss Physcomitrella patens through so-called gene targeting in order to study gene function in the moss.

As expected, these knockout mosses accumulated phenylalanine. In contrast to humans with phenylketonuria, however, the increased concentration of amino acids had no negative effect on the development of the moss. „Evidently, Physcomitrella has a previously unknown detoxification mechanism which has been lost in humans," explains Reski with regard to this surprising discovery.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pribat et al. Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts. Plant Cell, 22, 3410-3422

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals." ScienceDaily. ScienceDaily, 14 December 2010. <www.sciencedaily.com/releases/2010/12/101214085543.htm>.
Albert-Ludwigs-Universität Freiburg. (2010, December 14). No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/12/101214085543.htm
Albert-Ludwigs-Universität Freiburg. "No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals." ScienceDaily. www.sciencedaily.com/releases/2010/12/101214085543.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) — The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) — Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins