Featured Research

from universities, journals, and other organizations

No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals

Date:
December 14, 2010
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Phenylketonuria is the most common metabolic disease in humans. It occurs when the so-called PAH gene is defective, thus preventing the amino acid phenylalanine from being metabolized to the amino acid tyrosine. This leads to an accumulation of phenylalanine and to severe developmental disorders. Researchers now report that the PAH gene is not only present in animals and humans, but also in algae, mosses, and coniferous trees.

Phenylketonuria is the most common metabolic disease in humans. It occurs when the so-called PAH gene is defective, thus preventing the amino acid phenylalanine from being metabolized to the amino acid tyrosine. This leads to an accumulation of phenylalanine and to severe developmental disorders.

Related Articles


In the current issue of the journal Plant Cell, an international research team at the University of Florida, the CNRS Institute in Grenoble, the Noble Foundation, and the University of Freiburg now reports that the PAH gene is not only present in animals and humans, but also in algae, mosses, and coniferous trees. The scientists have not yet succeeded in discovering this gene in flowering plants.

The biologists in Freiburg, led by Prof. Dr. Ralf Reski, switched off the PAH gene in the moss Physcomitrella patens through so-called gene targeting in order to study gene function in the moss.

As expected, these knockout mosses accumulated phenylalanine. In contrast to humans with phenylketonuria, however, the increased concentration of amino acids had no negative effect on the development of the moss. „Evidently, Physcomitrella has a previously unknown detoxification mechanism which has been lost in humans," explains Reski with regard to this surprising discovery.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pribat et al. Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts. Plant Cell, 22, 3410-3422

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals." ScienceDaily. ScienceDaily, 14 December 2010. <www.sciencedaily.com/releases/2010/12/101214085543.htm>.
Albert-Ludwigs-Universität Freiburg. (2010, December 14). No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/12/101214085543.htm
Albert-Ludwigs-Universität Freiburg. "No phenylketonuria in certain plants: PAH gene found to be present in plants as well as animals." ScienceDaily. www.sciencedaily.com/releases/2010/12/101214085543.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins