Featured Research

from universities, journals, and other organizations

Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother

Date:
March 13, 2011
Source:
University of Pennsylvania School of Medicine
Summary:
For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home. Blending electrophysiological, biochemical and behavioral experiments, researchers demonstrated that neurons in the noses of mice mature after birth.

Wild-type mouse pups prefer their biological mother (upper), while the olfactory marker protein knockout mice do not show a preference between their mother and an unrelated, lactating female.
Credit: Minghong Ma, PhD, University of Pennsylvania School of Medicine

For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home.

Blended electrophysiological, biochemical, and behavioral experiments, Minghong Ma, PhD, an associate Professor of Neuroscience at the University of Pennsylvania School of Medicine, led a study published in a recent issue of the Journal of Neuroscience. With students Anderson Lee and Jiwei He, she demonstrated that neurons in the noses of mice mature after birth.

Using patch-clamping -- a technique that measures electrical signals at the cellular level -- Ma's team found that between birth and day 30 of development, normal neurons become six times more sensitive to their sibling's scent, in this case, a fragrance called lyral. In addition, the mice transition from a relative indiscriminate response to different odors to being highly attuned to one specific smell. They also respond to that specific odor with a faster speed over time.

The olfactory marker protein (OMP) likely mediates this developmental maturation. In olfactory sensory neurons lacking OMPs, response fails to speed up over 30 days as compared to normal neurons. The authors suggest this could be due to altered intracellular communication, since loss of the protein is associated with decreased phosphorylation of an associated enzyme called adenylate cyclase, a key player in the chemical signaling underlying the sense of smell.

The team also used a novel behavioral assay to illustrate one consequence of mistakes in this cellular maturation process. Normal mouse pups, given the choice between their mother and an unrelated, lactating female, will choose to huddle with or suckle their mother 78 percent of the time. But in the absence of OMP, newborn mice fail to make that distinction.

According to Ma, the maturation of olfaction in early development could offer animals that need nursing and care for a long time before maturing (altricial species, including some mammals) a survival advantage. Rather than being hard-wired at birth, Ma says, they learn to identify their surroundings and their family. "They actually learn to find their mother, home, and siblings, and to stay alive," she says. But whether the same is true of human infants, of course, remains an open question.

One key question yet to be addressed, Ma says, is the mechanism underlying this olfactory tuning process. How, for instance, do the cells develop a faster response speed? How do they get so good at focusing on just one odorant to the exclusion of all others? And can this process be modulated by early experience? The answers to those questions, she says, could possibly provide tools to influence the bonding between mother and child in early development, and even promote social interactions in autistic children.

The article was funded by the National Institute on Deafness and Other Communication Disorders, National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. C. Lee, J. He, M. Ma. Olfactory Marker Protein Is Critical for Functional Maturation of Olfactory Sensory Neurons and Development of Mother Preference. Journal of Neuroscience, 2011; 31 (8): 2974 DOI: 10.1523/JNEUROSCI.5067-10.2011

Cite This Page:

University of Pennsylvania School of Medicine. "Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother." ScienceDaily. ScienceDaily, 13 March 2011. <www.sciencedaily.com/releases/2011/03/110311165223.htm>.
University of Pennsylvania School of Medicine. (2011, March 13). Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2011/03/110311165223.htm
University of Pennsylvania School of Medicine. "Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother." ScienceDaily. www.sciencedaily.com/releases/2011/03/110311165223.htm (accessed August 20, 2014).

Share This




More Mind & Brain News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com
Mental, Neurological Disabilities Up 21% Among Kids

Mental, Neurological Disabilities Up 21% Among Kids

Newsy (Aug. 18, 2014) New numbers show a decade's worth of changes in the number of kids with disabilities. They suggest mental disabilities are up; physical ones are down. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins