Featured Research

from universities, journals, and other organizations

Probiotics: Sugar-coating promotes survival and reduces infection

Date:
January 23, 2012
Source:
Alimentary Pharmabiotic Centre - University College Cork
Summary:
Scientists have garnered new insights into how probiotic bacteria provide positive health benefits.

New insights into how probiotic bacteria provide positive health benefits have been published in the journal Proceedings of the National Academy of Sciences.

The research, carried out by Saranna Fanning and Lindsay Hall and led by Professor Douwe van Sinderen and his colleagues at the Alimentary Pharmabiotic Centre in UCC along with collaborators at The Wellcome Trust Sanger Institute in Cambridge, UK, showed that the outer coating surrounding the probiotic Bifidobacterium breve UCC2003 plays a key role in its survival in the gut, its evasion of the immune system and is also involved in reducing infection levels of a gut pathogen.

Probiotics are bacteria which have been shown to have health benefits such as inhibition of cancer, reduction of infections and reduction of relapse in ulcerative colitis. However, the exact mechanisms underlying these health-promoting claims have remained unknown.

"In this study we have shown that the outer EPS (exocellular polysaccharide) coating of Bifidobacterium breve UCC2003 protects the bacteria from acid and bile in the gut and shields the bacteria from the host immune response. Mutants in which the EPS genes have been deleted were found to evoke stronger immune responses. The EPS coating was also shown to prevent colonisation by a gut pathogen Citrobacter rodentium in mice. This surface EPS-dependent pathogen defence represents an exciting new avenue for probiotic research" said Douwe van Sinderen, senior author on the publication. "This research has led to an improved understanding of how probiotic bifidobacteria contribute to human and animal health, thereby will help to support their inclusion in functional foods."

The research, funded by Science Foundation Ireland, the Wellcome Trust and an EMBARK Postgraduate Scholarship and Travelling Studentship in the Sciences from IRCSET , is a culmination of several years' work by the researchers led by Professor Douwe van Sinderen at the Alimentary Pharmabiotic Centre and Professor Gordon Dougan at The Wellcome Trust Sanger Institute in Cambridge.


Story Source:

The above story is based on materials provided by Alimentary Pharmabiotic Centre - University College Cork. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Fanning, L. J. Hall, M. Cronin, A. Zomer, J. MacSharry, D. Goulding, M. O'Connell Motherway, F. Shanahan, K. Nally, G. Dougan, D. van Sinderen. Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1115621109

Cite This Page:

Alimentary Pharmabiotic Centre - University College Cork. "Probiotics: Sugar-coating promotes survival and reduces infection." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120123163131.htm>.
Alimentary Pharmabiotic Centre - University College Cork. (2012, January 23). Probiotics: Sugar-coating promotes survival and reduces infection. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/01/120123163131.htm
Alimentary Pharmabiotic Centre - University College Cork. "Probiotics: Sugar-coating promotes survival and reduces infection." ScienceDaily. www.sciencedaily.com/releases/2012/01/120123163131.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins