Featured Research

from universities, journals, and other organizations

Toward an alternative for antibiotics to fight bacterial infections?

Date:
July 4, 2012
Source:
VIB
Summary:
Mice that do not produce the receptor protein NLRP6, are better protected against bacterial infections and can more easily remove bacteria from the body. Therapeutic drugs that neutralize NLRP6 could be a possible treatment option, in addition to the use of antibiotics, for fighting bacterial infections.

Bacteria.
Credit: Copyright VIB

​VIB researcher Mohamed Lamkanfi, connected with Ghent University, discovered that mice that do not produce the receptor protein NLRP6, are better protected against bacterial infections and can more easily remove bacteria from the body. Therapeutic drugs that neutralize NLRP6 could be a possible treatment option, in addition to the use of antibiotics, for fighting bacterial infections.

Related Articles


His research was published in the journal Nature.

Mohamed Lamkanfi (VIB -- Ghent University) said "Our lab investigates the role of the innate immunity, which is of crucial importance to protect the body against bacteria and other pathogens. We started looking for genetic mutations that lead to an increased sensitivity to infections. Our research showed that mice with NLRP6 are less resistant to bacteria and have greater difficulty removing the bacteria from the body. This NLRP6 plays a disastrous role in the entire process."

New therapeutic track?

The discovery of Mohamed Lamkanfi is significant. The first line treatment for bacterial infections is and will remain antibiotics, of course. However, the intensive use of antibiotics in the fight against infections leads to antibiotic resistance. Sometimes this makes it much more difficult for doctors to treat a patient efficiently.

Mohamed Lamkanfi: "Our search for products to help immune systems in the fight against bacterial infections is very important. In spite of the availability of antibiotics bacterial infections continue to pose a serious threat to public health all over the world. Now that we have exposed the role of the receptor protein NLRP6 in the immune response, we can start thinking about the clinical application thereof for the treatment of bacterial infections. A vaccine, in my opinion, seems less suitable, but a medicine that neutralizes the receptor protein NLRP6, is a possibility. Of course not in the immediate future, but it does deserve all the attention to research this further."


Story Source:

The above story is based on materials provided by VIB. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paras K. Anand, R. K. Subbarao Malireddi, John R. Lukens, Peter Vogel, John Bertin, Mohamed Lamkanfi, Thirumala-Devi Kanneganti. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature, 2012; DOI: 10.1038/nature11250

Cite This Page:

VIB. "Toward an alternative for antibiotics to fight bacterial infections?." ScienceDaily. ScienceDaily, 4 July 2012. <www.sciencedaily.com/releases/2012/07/120704124101.htm>.
VIB. (2012, July 4). Toward an alternative for antibiotics to fight bacterial infections?. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/07/120704124101.htm
VIB. "Toward an alternative for antibiotics to fight bacterial infections?." ScienceDaily. www.sciencedaily.com/releases/2012/07/120704124101.htm (accessed October 31, 2014).

Share This



More Plants & Animals News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How A Chorus Led Scientists To A New Frog Species

How A Chorus Led Scientists To A New Frog Species

Newsy (Oct. 30, 2014) A frog noticed by a conservationist on New York's Staten Island has been confirmed as a new species after extensive study and genetic testing. Video provided by Newsy
Powered by NewsLook.com
Surfer Accidentally Stands on Shark, Gets Bitten

Surfer Accidentally Stands on Shark, Gets Bitten

AP (Oct. 30, 2014) A 20-year-old competition surfer said on Thursday he accidentally stepped on a shark's head before it bit him off the Australian east coast. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Ebola Inflicts Heavy Toll on Guinean Potato Trade

Ebola Inflicts Heavy Toll on Guinean Potato Trade

AFP (Oct. 30, 2014) The Ebola epidemic has seen Senegal and Guinea Bissau close its borders with Guinea and the economic consequences have started to be felt, especially in Fouta Djallon, where the renowned potato industry has been hit hard. Duration: 02:01 Video provided by AFP
Powered by NewsLook.com
Genetically Altered Glowing Flower on Display in Tokyo

Genetically Altered Glowing Flower on Display in Tokyo

Reuters - Innovations Video Online (Oct. 30, 2014) Just in time for Halloween, a glowing flower goes on display in Tokyo. Instead of sorcery and magic, its creators used science to genetically modify the flower, adding a naturally fluorescent plankton protein to its genetic mix. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Innate Immune System Protein Provides a New Target in War Against Bacterial Infections

July 2, 2012 Scientists have identified a possible new approach to defeating bacterial infections by targeting an innate immune system component in a bid to invigorate the immune ... read more

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins