Featured Research

from universities, journals, and other organizations

Grape seed extract bollixes norovirus

Date:
November 8, 2012
Source:
American Society for Microbiology
Summary:
Norovirus causes more than half of all food-born illnesses in the United States, and is the second greatest source of reported food borne illness outbreaks in the European Union. A recent study found that grape seed extract could reduce the infectivity of Norovirus surrogates (Norovirus surrogates are viruses that share pathological and/or biological features with human norovirus). Now, researchers have shown that grape seed extract does so by denaturing the capsid protein, which is the coat of the virus, thereby disabling the virus.

Slice of red grape, showing seeds.
Credit: HamsterMan / Fotolia

Norovirus causes more than half of all food-born illnesses in the United States, and is the second greatest source of reported food borne illness outbreaks in the European Union. A recent study found that grape seed extract could reduce the infectivity of Norovirus surrogates (Norovirus surrogates are viruses that share pathological and/or biological features with human norovirus). Now, Dan Li of Ghent University, Ghent, Belgium and collaborators have shown that grape seed extract does so by denaturing the capsid protein, which is the coat of the virus, thereby disabling the virus.

The research is published in the November 2012 issue of Applied and Environmental Microbiology.

In the study, the researchers observed that under treatment with grape seed extract, at low doses, the spherically-shaped murine (mouse) norovirus-1 coat proteins clumped, and showed "obvious deformation and inflation," according to the report. At higher doses, the researchers saw no coat proteins, only protein debris. "This provides evidence that [grape seed extract] could effectively damage the [norovirus] capsid protein, which could reduce viral binding ability and infectivity accordingly," according to the report.

The researchers used surrogate viruses because there are no suitable animal models of norovirus, and human norovirus has been impossible to propagate in cell cultures. The surrogate virus, murine norovirus-1, can be grown in cell culture, and belongs to the same genus as human norovirus, and has a very similar genome structure, and morphology. Nonetheless, the researchers were able to measure the specific binding strength of human norovirus by two different methods, finding that it declined precipitously under the influence of grape seed extract, providing further support to their results.

Norovirus is transmitted mainly fecal-orally, and infected food handlers, contaminated water, and surfaces can be identified as important sources of transmission, "which could further contaminate ready-to-eat foods, drinking water, shellfish, and fresh produce," says Li. A mere 10-100 virus particles are sufficient to transmit the disease.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Li, L. Baert, D. Zhang, M. Xia, W. Zhong, E. Van Coillie, X. Jiang, M. Uyttendaele. Effect of Grape Seed Extract on Human Norovirus GII.4 and Murine Norovirus 1 in Viral Suspensions, on Stainless Steel Discs, and in Lettuce Wash Water. Applied and Environmental Microbiology, 2012; 78 (21): 7572 DOI: 10.1128/AEM.01987-12

Cite This Page:

American Society for Microbiology. "Grape seed extract bollixes norovirus." ScienceDaily. ScienceDaily, 8 November 2012. <www.sciencedaily.com/releases/2012/11/121108195701.htm>.
American Society for Microbiology. (2012, November 8). Grape seed extract bollixes norovirus. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/11/121108195701.htm
American Society for Microbiology. "Grape seed extract bollixes norovirus." ScienceDaily. www.sciencedaily.com/releases/2012/11/121108195701.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Adorable Video of Baby Rhino and Lamb Friend Playing

Adorable Video of Baby Rhino and Lamb Friend Playing

Buzz60 (Oct. 20, 2014) Gertjie the Rhino and Lammie the Lamb are teaching the world about animal conservation and friendship. TC Newman (@PurpleTCNewman) has the adorable video! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins