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New anticoagulant discovered based on the same used by malaria vectors to feed on

Date:
December 11, 2012
Source:
IMIM (Hospital del Mar Medical Research Institute)
Summary:
An international project has, for the first time ever, deciphered the mechanism by which a substance called anophelin binds to an enzyme (thrombin) involved in the process of blood coagulation. This discovery opens the door to designing a new generation of anticoagulant drugs with a totally different functioning to current ones and also to fighting against the spreading of malaria by designing inhibitors for this substance.

An international project lead by the Molecular and Cell Biology Institute of Porto University with the participation of researchers from IMIM (Hospital del Mar Medical Research Institute) has, for the first time ever, deciphered the mechanism by which a substance called anophelin binds to an enzyme (thrombin) involved in the process of blood coagulation.

This discovery was published in the last issue of the Proceedings of the National Academy of Sciences and opens the door to, on the one hand, designing a new generation of anticoagulant drugs with a totally different functioning to current ones and, on the other hand, fighting against the spreading of malaria by designing inhibitors for this substance.

Anophelin is a substance playing a crucial role in the nutrition of a large number of parasites like malaria-carrying Anopheles mosquitoes or vampire bats. These animals need to feed on fresh blood and stop it from coagulating while they are eating. To make this possible, they use powerful inhibitors of the coagulation process mainly affecting thrombin. Researchers have discovered that "anophelin blocks thrombin in a new and different way than other substances: it's like a key fitting in a lock of a door, but in this case the key fits in the other side," explains Ricardo Gutiérrez Gallego, a member of the IMIM Bioanalysis research group.

The project is based on two recent studies which led to the discovery of thrombin inhibitors presenting new structures. For the inhibitor produced by Anopheles mosquitoes (anophelin), it was seen that after binding to thrombin, proteins did not degrade, so a systematic study was launched for all coagulants in the several variants of the Anopheles mosquito. By using very powerful and sensitive analytical techniques it was possible to determine and monitor in real time the molecule interactions in both anophelin and thrombin, leading to a detailed characterization of their structure and interaction. Researchers also performed mutations on this protein, i.e. they changed the amino acid at each time, so as to discover the crucial components of the molecule when it interacted with thrombin.

Blood coagulation is a complex mechanism to prevent bleeding after an injury. However, in some cases, the formation of blood clots can lead to a myocardial infarction, a cerebral infarction etc. In these cases, administering anticoagulants is essential. Anticoagulants are drugs that prevent blood from coagulating, thus avoiding cardiovascular events, which are the leading cause of death in Spain. In recent years, one of the most active fields of research has been the search for the ideal anticoagulant since the ones available today may have side effects and must be administered under strict medical control. "The discovery of this new interaction could be useful in the future to create new generation anticoagulant drugs that improve these aspects and also to fight against the spreading of malaria," concludes Dr. Gutiérrez Gallego.

This project has lasted 3 years also with the participation of the Hospital de Sant Pau in Barcelona and the European Synchrotron Radiation Facility (ESRF) in Grenoble; it was funded by the Ministry of Science and Innovation and by the Fundação para a Ciência e a Tecnologia in Portugal.


Story Source:

The above story is based on materials provided by IMIM (Hospital del Mar Medical Research Institute). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. C. Figueiredo, D. de Sanctis, R. Gutierrez-Gallego, T. B. Cereija, S. Macedo-Ribeiro, P. Fuentes-Prior, P. J. B. Pereira. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1211614109

Cite This Page:

IMIM (Hospital del Mar Medical Research Institute). "New anticoagulant discovered based on the same used by malaria vectors to feed on." ScienceDaily. ScienceDaily, 11 December 2012. <www.sciencedaily.com/releases/2012/12/121211113112.htm>.
IMIM (Hospital del Mar Medical Research Institute). (2012, December 11). New anticoagulant discovered based on the same used by malaria vectors to feed on. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/12/121211113112.htm
IMIM (Hospital del Mar Medical Research Institute). "New anticoagulant discovered based on the same used by malaria vectors to feed on." ScienceDaily. www.sciencedaily.com/releases/2012/12/121211113112.htm (accessed April 19, 2014).

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