Featured Research

from universities, journals, and other organizations

First cell movements in the embryo decoded

Date:
March 12, 2013
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Scientist have elucidated the molecular control mechanisms that transform the initially tightly cohesive earliest cells of the zebrafish embryo so that the first major cell migration in their development is initiated.

Groups of red and green labelled cells in a zebrafish during their first migration.
Credit: Image courtesy of Albert-Ludwigs-Universität Freiburg

A research team of the University of Freiburg has elucidated the molecular control mechanisms that transform the initially tightly cohesive earliest cells of the zebrafish embryo so that the first major cell migration in their development is initiated. The researchers from the Department of Developmental Biology of the Institute of Biology I, the Center for Biological Systems Analysis, and BIOSS Centre for Biological Signalling Studies, the Cluster of Excellence of the University of Freiburg, under the direction of Prof. Dr. Wolfgang Driever have published the results in the current issue of the scientific journal Developmental Cell.

Related Articles


A better understanding of cell migration is of high biomedical relevance. Whereas for a healthy human or animal body cell movements are for example essential for wound healing, it may be lethal when cancer cells start to migrate into the body and induce metastases. Cell migration can be studied especially well during embryogenesis of model organisms such as the zebrafish, because it develops in the water, and the movements of each cell can be observed under the microscope.

Following fertilization of the egg, during the next cell divisions all cells of the embryo have to stick together tightly. Otherwise the embryo may split into parts. Shortly thereafter, cells have to start to migrate to build the germ layers of the embryo. To accomplish this, the tight connections have to be resolved. The biologists from Freiburg were able to show that the important stem cell factor Oct4 controls the synthesis of a signal, the epidermal growth factor (EGF), which in turn controls the transport of the crucial cell adhesion molecule E-Cadherin from the cell membrane to the interior of the cell in endosomes. These mechanisms regulate the activity of E-Cadherin at the cell membrane and enable cells to dynamically form new connections and start to move.

The project was performed in the Collaborative Research Center (SFB 850) "Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis." The results are relevant for potential mechanisms involved in cancer metastasis, because similar regulations involving EGF and E-Cadherin contribute to the so-called epithelio-mesenchymal transition that may initiate tumour invasion. Furthermore, the contribution of the stem cell factor Oct4 is crucial to study the properties of cancer stem cells.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sungmin Song, Stephanie Eckerle, Daria Onichtchouk, James A. Marrs, Roland Nitschke, Wolfgang Driever. Pou5f1-Dependent EGF Expression Controls E-Cadherin Endocytosis, Cell Adhesion, and Zebrafish Epiboly Movements. Developmental Cell, 2013; 24 (5): 486 DOI: 10.1016/j.devcel.2013.01.016

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "First cell movements in the embryo decoded." ScienceDaily. ScienceDaily, 12 March 2013. <www.sciencedaily.com/releases/2013/03/130312092531.htm>.
Albert-Ludwigs-Universität Freiburg. (2013, March 12). First cell movements in the embryo decoded. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2013/03/130312092531.htm
Albert-Ludwigs-Universität Freiburg. "First cell movements in the embryo decoded." ScienceDaily. www.sciencedaily.com/releases/2013/03/130312092531.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Aquaponics Turn Suburban Industrial Park Into Farmland: Hume

Aquaponics Turn Suburban Industrial Park Into Farmland: Hume

The Toronto Star (Jan. 27, 2015) — Ancient techniques of growing greens with fish and water are well ahead of Toronto bylaws. Video provided by The Toronto Star
Powered by NewsLook.com
Chihuahua Sleeps on Top of Great Dane

Chihuahua Sleeps on Top of Great Dane

Rumble (Jan. 27, 2015) — As this giant Great Dane lays down for bedtime he accompanied by an adorable companion. Watch a tiny Chihuahua jump up and prepare to sleep on top of his friend. Now that&apos;s a pretty big bed! Credit to &apos;emma_hussey01&apos;. Video provided by Rumble
Powered by NewsLook.com
Madagascar Locust Plague Could Mean Famine For Millions

Madagascar Locust Plague Could Mean Famine For Millions

Newsy (Jan. 27, 2015) — The Food and Agriculture Organization says millions could face famine in Madagascar without more funding to finish locust eradication efforts. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins