Featured Research

from universities, journals, and other organizations

Insight into breast cancer cell migration

Date:
October 28, 2013
Source:
University of Kentucky
Summary:
A new study shows that a specific protein may assist breast cancer cells in metastasizing.

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.
Credit: University of Kentucky

A new study by University of Kentucky Markey Cancer Center researchers Min Chen and Kathleen O'Connor shows that a specific protein may assist breast cancer cells in metastasizing.

Tumor cells escape a primary tumor by a process called invasion. This process of invasion requires cells to migrate or move through tissue. This process is controlled by the restructuring of the actin cytoskeleton.

Signal transduction through the Rho-ROCK pathway can regulate the reorganization of the actin cytoskeleton such that it can form membrane ruffles at the front of a cell, which is used to efficiently move the cell forward, and form strong tension fibers (often referred to as stress fibers) within the body of the cell.

Published in Oncogene, the study found that a metastasis-associated protein known as S100A4 or metastasin can switch Rho function from making stress fibers to creating membrane ruffles.

Stress fibers are associated with non-motile cells, while their absence when coupled with the presence of membrane ruffles at the leading edge of cells is associated with cell migration and tumor invasion.

"Finding that S100A4 changes how Rho functions is a huge breakthrough and helps us to understand better how these two proteins contribute to metastasis," said O'Connor, professor in the Department of Molecular and Cellular Biochemistry at UK. "My lab is continuing to figure out just how these two proteins interact to drive invasion and metastasis. We are using this information to design better therapies for cancer patients. Currently, we do not have drugs that combat tumor invasion or metastasis despite the fact that metastasis is the major cause of cancer patient deaths. It is our hope that soon we will determine how to use selective drugs to target these pathways and improve the lives of cancer patients."

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.


Story Source:

The above story is based on materials provided by University of Kentucky. The original article was written by Allison Perry. Note: Materials may be edited for content and length.


Cite This Page:

University of Kentucky. "Insight into breast cancer cell migration." ScienceDaily. ScienceDaily, 28 October 2013. <www.sciencedaily.com/releases/2013/10/131028184803.htm>.
University of Kentucky. (2013, October 28). Insight into breast cancer cell migration. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/10/131028184803.htm
University of Kentucky. "Insight into breast cancer cell migration." ScienceDaily. www.sciencedaily.com/releases/2013/10/131028184803.htm (accessed July 28, 2014).

Share This




More Plants & Animals News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com
Russia Saves Gecko Sex Satellite, Media Has Some Fun With It

Russia Saves Gecko Sex Satellite, Media Has Some Fun With It

Newsy (July 27, 2014) The satellite is back under ground control after a tense few days, but with a gecko sex experiment on board, the media just couldn't help themselves. Video provided by Newsy
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins