Featured Research

from universities, journals, and other organizations

Insight into breast cancer cell migration

Date:
October 28, 2013
Source:
University of Kentucky
Summary:
A new study shows that a specific protein may assist breast cancer cells in metastasizing.

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.
Credit: University of Kentucky

A new study by University of Kentucky Markey Cancer Center researchers Min Chen and Kathleen O'Connor shows that a specific protein may assist breast cancer cells in metastasizing.

Related Articles


Tumor cells escape a primary tumor by a process called invasion. This process of invasion requires cells to migrate or move through tissue. This process is controlled by the restructuring of the actin cytoskeleton.

Signal transduction through the Rho-ROCK pathway can regulate the reorganization of the actin cytoskeleton such that it can form membrane ruffles at the front of a cell, which is used to efficiently move the cell forward, and form strong tension fibers (often referred to as stress fibers) within the body of the cell.

Published in Oncogene, the study found that a metastasis-associated protein known as S100A4 or metastasin can switch Rho function from making stress fibers to creating membrane ruffles.

Stress fibers are associated with non-motile cells, while their absence when coupled with the presence of membrane ruffles at the leading edge of cells is associated with cell migration and tumor invasion.

"Finding that S100A4 changes how Rho functions is a huge breakthrough and helps us to understand better how these two proteins contribute to metastasis," said O'Connor, professor in the Department of Molecular and Cellular Biochemistry at UK. "My lab is continuing to figure out just how these two proteins interact to drive invasion and metastasis. We are using this information to design better therapies for cancer patients. Currently, we do not have drugs that combat tumor invasion or metastasis despite the fact that metastasis is the major cause of cancer patient deaths. It is our hope that soon we will determine how to use selective drugs to target these pathways and improve the lives of cancer patients."

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.


Story Source:

The above story is based on materials provided by University of Kentucky. The original article was written by Allison Perry. Note: Materials may be edited for content and length.


Cite This Page:

University of Kentucky. "Insight into breast cancer cell migration." ScienceDaily. ScienceDaily, 28 October 2013. <www.sciencedaily.com/releases/2013/10/131028184803.htm>.
University of Kentucky. (2013, October 28). Insight into breast cancer cell migration. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/10/131028184803.htm
University of Kentucky. "Insight into breast cancer cell migration." ScienceDaily. www.sciencedaily.com/releases/2013/10/131028184803.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com
Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins