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Key role of protein in segregation of genetic material during cell division

Date:
December 11, 2013
Source:
IDIBELL-Bellvitge Biomedical Research Institute
Summary:
Researchers have reported the regulator mechanisms of mitosis, a key stage of the cell-cycle for the correct transmission of genetic information from parents to sons.

Researchers at the Cell Cycle Research Group of the Bellvitge Institute of Biomedical Research (IDIBELL) led by Ethel Queralt have reported in the journal PLoS Genetics an article which delve into the regulator mechanisms of mitosis, a key stage of the cell-cycle for the correct transmision of genetic information from parents to sons.

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Cell-cycle

Cells in all organisms grow and divide into two daughter cells by an ordered sequence of events called "cell cycle." Basically , the cells have to complete four main processes during the cell cycle : growth ( G1 and G2 phases ) , doubling the DNA ( S phase ) , segregate chromosomes ( M phase , mitosis) and divide ( cytokinesis ) .

In the S phase , or replication of DNA, the genetic material doubles and then, during the M phase or mitosis, the cells separate the duplicated chromosomes into the two daughter cells. In this way the correct inheritance of genetic information from one generation of cells to the next is assured. The transmission of genetic information (DNA ) from parent to child (or equivalently , from cell to cell ) is a fundamental question in biology .

Aneuploidy , ie lack or excess of chromosomes, is a feature present in almost all human cancers and promotes tumor development . The regulation of mitosis is particularly important to maintain chromosome stability : for example , the aneuploid tumor cells arise as a consequence of defects in chromosome segregation , which originate in cells with varying normal genetic material . However, despite its importance , little is known of the regulation of mitotic exit .

The Hippo tumor suppressor pathway

The article published in the journal Plos Genetics decribes the latest advances in the mechanisms of regulation of mitotic exit . The protein called ' separase " is a key component for proper chromosome segregation and the regulation of mitosis. In previous work Queralt group first described the involvement of protein phosphatase PP2A in mitosis. These proteins cooperate with 'separase' to ensure correct genetic inheritance between cells .

" In this study," explained Queralt " we have delved into the molecular mechanism by which this protein PP2A regulates mitosis and contributes to the correct segregation of chromosomes by identifying two new substrates , two components of the route Hippo tumor suppressor -- " .

As explained by the researcher " in recent times are very powerful publishing studies on the use of this pathway as a therapeutic target in cancer. However, in my opinion , before that, we should better understand their molecular mechanisms. " In that sense it said that " this work contributes to advancing knowledge of Hippo tumor suppressor pathway on the regulation of mitosis. And the application of such basic knowledge will help develop more specific and direct against different types of cancer treatments.


Story Source:

The above story is based on materials provided by IDIBELL-Bellvitge Biomedical Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Baro B., Calabria I., Rodríguez-Rodríguez J.A., Hernáez M.L. Gil C. and Queralt E. Dual regulation of the Mitotic Exit Network (MEN) by PP2A-Cdc55 phospatase. PLoS Genetics, December 2013

Cite This Page:

IDIBELL-Bellvitge Biomedical Research Institute. "Key role of protein in segregation of genetic material during cell division." ScienceDaily. ScienceDaily, 11 December 2013. <www.sciencedaily.com/releases/2013/12/131211093924.htm>.
IDIBELL-Bellvitge Biomedical Research Institute. (2013, December 11). Key role of protein in segregation of genetic material during cell division. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/12/131211093924.htm
IDIBELL-Bellvitge Biomedical Research Institute. "Key role of protein in segregation of genetic material during cell division." ScienceDaily. www.sciencedaily.com/releases/2013/12/131211093924.htm (accessed October 25, 2014).

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