Featured Research

from universities, journals, and other organizations

Research team discovers new regulators of most prevalent liver disease

Date:
January 7, 2014
Source:
Centro Nacional de Investigaciones Oncologicas (CNIO)
Summary:
Researchers have discovered novel factors, the AP-1 proteins, which are critically involved in fatty liver disease pathogenesis.

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

The Genes, Development and Disease research team led by Erwin Wagner, head of the BBVA Foundation-Spanish National Cancer Research Centre (CNIO) Cancer Cell Biology Programme, in collaboration with Johan Auwerx from the EPFL in Lausanne, have discovered novel factors, the AP-1 proteins, which are critically involved in FLD pathogenesis. These results are featured on the cover of the latest issue of Cell Metabolism, the leading journal in the field of metabolism.

The CNIO team found that the AP-1 gene Fra-1 is reduced in the liver of obese mice. To study the functional contribution of these proteins to fat metabolism in the liver, researchers used transgenic mice with increased or decreased AP-1 expression in the liver.

Strikingly, increased expression of some of these genes, such as Fra-1 or Fra-2, in the liver of mice completely prevented the accumulation of fat and FLD. "In humans, unhealthy diet is the main cause of FLD. Therefore, we used a fat-rich diet to induce obesity and FLD in mice. When we switched on Fra-1 in the liver, all the fat disappeared, the effect was stunning," states first author Sebastian Hasenfuss. In addition, Fra-1 also prevented inflammation and liver damage in obese mice.

The CNIO researchers describe the mechanism underlying the effect of AP-1 proteins on fat metabolism. "AP-1 proteins are master regulators of fat metabolism," explains corresponding author Erwin Wagner. He adds that "these proteins control how the liver takes up fat from the blood stream."

Interestingly, the AP-1 proteins c-Fos or JunD, which are related to the Fra proteins, had the opposite effect on fat metabolism in the liver. The CNIO research team proposes that the imbalance between the different AP-1 proteins represents a key step in FLD pathogenesis.


Story Source:

The above story is based on materials provided by Centro Nacional de Investigaciones Oncologicas (CNIO). Note: Materials may be edited for content and length.


Journal Reference:

  1. SebastianC. Hasenfuss, Latifa Bakiri, MartinK. Thomsen, EvanG. Williams, Johan Auwerx, ErwinF. Wagner. Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers. Cell Metabolism, 2014; 19 (1): 84 DOI: 10.1016/j.cmet.2013.11.018

Cite This Page:

Centro Nacional de Investigaciones Oncologicas (CNIO). "Research team discovers new regulators of most prevalent liver disease." ScienceDaily. ScienceDaily, 7 January 2014. <www.sciencedaily.com/releases/2014/01/140107135805.htm>.
Centro Nacional de Investigaciones Oncologicas (CNIO). (2014, January 7). Research team discovers new regulators of most prevalent liver disease. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2014/01/140107135805.htm
Centro Nacional de Investigaciones Oncologicas (CNIO). "Research team discovers new regulators of most prevalent liver disease." ScienceDaily. www.sciencedaily.com/releases/2014/01/140107135805.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins