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Cannabis during pregnancy endangers fetal brain development

Date:
January 27, 2014
Source:
Karolinska Institutet
Summary:
The consumption of Cannabis during pregnancy can impair the development of the fetus' brain with long-lasting effects after birth. Cannabis is particularly powerful to derail how nerve cells form connections, potentially limiting the amount of information the affected brain can process, new research shows.

An increasing number of children suffer from the consequences of maternal drug exposure during pregnancy, and Cannabis is one of the most frequently used substances. This motivated the study, published in the EMBO Journal, conducted in mice and human brain tissue, to decipher the molecular basis of how the major psychoactive component from Cannabis called delta-9-tetrahydrocannabinol or THC affects brain development of the unborn fetus.

The study highlights that consuming Cannabis during pregnancy clearly results in defective development of nerve cells of the cerebral cortex, the part of the brain that orchestrates higher cognitive functions and drives memory formation. In particular, THC negatively impacts if and how the structural platform and conduit for communication between nerve cells, the synapses and axons, will develop and function. Researchers also identified Stathmin-2 as a key protein target for THC action, and its loss is characterized as a reason for erroneous nerve growth. It is stressed that Cannabis exposure in experimental models precisely coincided with the fetal period when nerve cells form connections amongst each other.

According to study leader Professor Tibor Harkany, who shares his time between Karolinska Institutet and the Medical University Vienna in Austria, these developmental deficits may evoke life-long modifications to the brain function of those affected. Even though not all children who have been exposed to Cannabis will suffer immediate and obvious deficits, Professor Harkany warns that relatively subtle damage can significantly increase the risk of delayed neuropsychiatric diseases.

"Even if THC only would cause small changes its effect may well be sufficient to sensitize the brain to later stressors or diseases to provoke neuropsychiatric illnesses in those affected in the future," says Professor Harkany. "This concerns also the medical use of Cannabis, which should be avoided during pregnancy."


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Giuseppe Tortoriello, Claudia V Morris, Alan Alpar, Janos Fuzik, Sally L Shirran, Daniela Calvigioni, Erik Keimpema, Catherine H Botting, Kirstin Reinecke, Thomas Herdegen, Michael Courtney, Yasmin L Hurd, Tibor Harkany. Miswiring the brain: Δ9‐tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin‐2 degradation pathway. EMBO Journal, January 2014

Cite This Page:

Karolinska Institutet. "Cannabis during pregnancy endangers fetal brain development." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127093140.htm>.
Karolinska Institutet. (2014, January 27). Cannabis during pregnancy endangers fetal brain development. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2014/01/140127093140.htm
Karolinska Institutet. "Cannabis during pregnancy endangers fetal brain development." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127093140.htm (accessed April 16, 2014).

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