Featured Research

from universities, journals, and other organizations

Epigenetic regulation required to ensure correct number of chromosomes

Date:
February 16, 2014
Source:
Karolinska Institutet
Summary:
Abnormal number of chromosomes is often associated with cancer development. Researchers have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes. Normally when a cell divides, the chromosomes are segregated equally to two daughter cells. However, tumor cells frequently have either too few or too many chromosomes, leading to the incorrect expression of a number of genes. When a cell is about to divide, the cell division machinery takes hold of chromosomes by the centromere so that they may be pulled apart and one copy of each given to the daughter cells.

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

Normally when a cell divides, the chromosomes are segregated equally to two daughter cells. However, tumor cells frequently have either too few or too many chromosomes, leading to the incorrect expression of a number of genes. When a cell is about to divide, the cell division machinery takes hold of chromosomes by the centromere so that they may be pulled apart and one copy of each given to the daughter cells.

In the current study, researchers have shown that an epigenetic process, involving the attachment of a small protein to the histone H2B (called H2Bub1), facilitates an important structural change of the centromere immediately prior to cell division. It was previously shown that enzymes that modify histone H2B in this way also play a role in protecting against cancer. This was previously linked to defects in chromosomal repair.

Our study confirms this role for H2Bub1, but we are extending it to include another mechanism that directly leads to the incorrect number of chromosomes in cells, says Peter Svensson at the Department of Biosciences and Nutrition, one of the researchers who conducted the study.

The researchers behind the new study say that the fact that this mechanism is highly similar in human cells and yeast cells suggests that it plays a key role in ensuring proper chromosome distribution following each cell division.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laia Sadeghi, Lee Siggens, J Peter Svensson, Karl Ekwall. Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity. Nature Structural & Molecular Biology, 2014; DOI: 10.1038/nsmb.2776

Cite This Page:

Karolinska Institutet. "Epigenetic regulation required to ensure correct number of chromosomes." ScienceDaily. ScienceDaily, 16 February 2014. <www.sciencedaily.com/releases/2014/02/140216151709.htm>.
Karolinska Institutet. (2014, February 16). Epigenetic regulation required to ensure correct number of chromosomes. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2014/02/140216151709.htm
Karolinska Institutet. "Epigenetic regulation required to ensure correct number of chromosomes." ScienceDaily. www.sciencedaily.com/releases/2014/02/140216151709.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com
Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins