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New findings on neurogenesis in spinal cord

Date:
March 5, 2014
Source:
Karolinska Institutet
Summary:
The expression of the so called MYC gene is important and necessary for neurogenesis in the spinal cord, new research suggests. The MYC gene encodes the protein with the same name, and has an important role in many cellular processes such as proliferation, metabolism, cell death and the potential of differentiation from immature stem cells to different types of specialized cells. Importantly it is also one of the most frequently activated genes in human cancer.
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Research from Karolinska Institutet in Sweden suggests that the expression of the so called MYC gene is important and necessary for neurogenesis in the spinal cord. The findings are being published in the journal EMBO Reports.

The MYC gene encodes the protein with the same name, and has an important role in many cellular processes such as proliferation, metabolism, cell death and the potential of differentiation from immature stem cells to different types of specialized cells. Importantly it is also one of the most frequently activated genes in human cancer.

Previously MYC has been shown to promote proliferation and inhibit differentiation in dissociated cells in culture. However, in the current study researchers demonstrate that in the intact neural tissue from chickens, MYC promotes differentiation of neural cells rather than their proliferation.

"We hope that this news knowledge can be important for developing future strategies to promote nerve cell development, for example in patients with spinal cord injuries," says principal investigator Marie Arsenian Henriksson, professor at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet.


Story Source:

The above post is reprinted from materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nikolay Zinin, Igor Adameyko, Margareta Wilhelm, Nicolas Fritz, Per Uhlén, Patrik Ernfors, Marie Arsenian Henriksson. MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division. EMBO Reports, March 2014 DOI: 10.1002/embr.201337424

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Karolinska Institutet. "New findings on neurogenesis in spinal cord." ScienceDaily. ScienceDaily, 5 March 2014. <www.sciencedaily.com/releases/2014/03/140305084602.htm>.
Karolinska Institutet. (2014, March 5). New findings on neurogenesis in spinal cord. ScienceDaily. Retrieved July 5, 2015 from www.sciencedaily.com/releases/2014/03/140305084602.htm
Karolinska Institutet. "New findings on neurogenesis in spinal cord." ScienceDaily. www.sciencedaily.com/releases/2014/03/140305084602.htm (accessed July 5, 2015).

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