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Tumor suppressor p53 cuts off invading cancer cells

Date:
March 24, 2014
Source:
The Rockefeller University Press
Summary:
The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells. Sometimes oncogenes manage to initiate tumor development in the presence of p53, which focuses its efforts instead on limiting the tumor’s ability to invade and metastasize. Researchers uncover one way that p53 acts to prevent cancer cell invasion.

Tumor cells expressing p53 (left) have fewer focal adhesions (red) and lower levels of active p130Cas (green)—rendering them noninvasive—compared with p53-deficient tumor cells (right).
Credit: Yamauchi et al., 2014

The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive. Sometimes oncogenes manage to initiate tumor development in the presence of p53, but, even then, the tumor suppressor doesn't give up and focuses its efforts instead on limiting the tumor's ability to invade and metastasize. A study in The Journal of Cell Biology uncovers one way that p53 acts to prevent cancer cell invasion.

A team of researchers, led by Keiko Kawauchi from the Mechanobiology Institute at the National University of Singapore, studied cells that had been transformed into cancer cells by Ras, the most common oncogene in human cancer. They compared Ras-transformed cells with and without p53 and observed that those expressing p53 were less invasive and formed fewer focal adhesions, the molecular linkages that connect the structural scaffolding within the cell to the extracellular matrix that surrounds the cell.

The researchers found that p53 limits invasion by initiating a chain of events that ultimately prevents the formation of lamellipodia, cell membrane protrusions that spur cell movement and invasion. p53 activates a mitochondrial protease called Omi, which is then released into the cytosol of the cell when Ras causes mitochondria to fragment. Omi cleaves actin filaments in the cytoskeleton, and the decrease in actin suppresses the activity of p130Cas, a focal adhesion signaling protein that promotes the formation of lamellipodia. With low levels of active p130Cas, cells don't form lamellipodia and are therefore less able to invade.

"Actin remodeling is a signal that prevents cell invasion," explains Kawauchi. "Most research has focused on how p53 prevents metastasis by regulating epithelial-to-mesenchymal transitions," a biological process by which cells gain migratory and invasive properties. In contrast, says Kawauchi, the new findings help explain how p53 affects the cytoskeletal processes within the cell that drive invasion.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shota Yamauchi, Yan Yan Hou, Alvin Kunyao Guo, Hiroaki Hirata, Wataru Nakajima, Ai Kia Yip, Cheng-Han Yu, Ichiro Harada, Keng-Hwee Chiam, Yasuhiro Sawada, Nobuyuki Tanaka, and Keiko Kawauchi. p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion. The Journal of Cell Biology, March 2014 DOI: 10.1083/jcb.201309107

Cite This Page:

The Rockefeller University Press. "Tumor suppressor p53 cuts off invading cancer cells." ScienceDaily. ScienceDaily, 24 March 2014. <www.sciencedaily.com/releases/2014/03/140324104318.htm>.
The Rockefeller University Press. (2014, March 24). Tumor suppressor p53 cuts off invading cancer cells. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/03/140324104318.htm
The Rockefeller University Press. "Tumor suppressor p53 cuts off invading cancer cells." ScienceDaily. www.sciencedaily.com/releases/2014/03/140324104318.htm (accessed July 28, 2014).

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